Treatment of Sympathomimetic Induced Intraventricular Hemorrhage with Intraventricular Urokinase

Wendy C. Ziai; Antigone Triantaphyllopoulou; Alexander Y. Razumovsky; Daniel F. Hanley

doi:10.1016/j.jstrokecerebrovasdis.2003.09.011

Treatment of Sympathomimetic Induced Intraventricular Hemorrhage with Intraventricular Urokinase

Wendy C. Ziai, Antigone Triantaphyllopoulou, Alexander Y. Razumovsky, Daniel F. Hanley

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Intraventricular hemorrhage (IVH) occurred in a 32-year-old man following the use of both ephedrine and pseudoephedrine. Cerebral angiography and transcranial Doppler studies showed changes suggestive of vasculitis. We describe the management and investigations of a unique case of IVH. This patient was treated with ventriculostomy and intraventricular urokinase (UK). A favorable outcome was obtained with independent function at 10 weeks post hemorrhage. The use of intraventricular thrombolysis for drug-induced IVH has not previously been reported, although it has been shown to be a safe and potentially beneficial intervention.

Original language	English (US)
Pages (from-to)	276-279
Number of pages	4
Journal	Journal of Stroke and Cerebrovascular Diseases
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/j.jstrokecerebrovasdis.2003.09.011
State	Published - 2003

Keywords

Intraventricular hemorrhage
Sympathomimetics
Thrombolysis
Urokinase

ASJC Scopus subject areas

Surgery
Rehabilitation
Clinical Neurology
Cardiology and Cardiovascular Medicine

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@article{49a79684d88b471e94f6fcc49c953adc,

title = "Treatment of Sympathomimetic Induced Intraventricular Hemorrhage with Intraventricular Urokinase",

abstract = "Intraventricular hemorrhage (IVH) occurred in a 32-year-old man following the use of both ephedrine and pseudoephedrine. Cerebral angiography and transcranial Doppler studies showed changes suggestive of vasculitis. We describe the management and investigations of a unique case of IVH. This patient was treated with ventriculostomy and intraventricular urokinase (UK). A favorable outcome was obtained with independent function at 10 weeks post hemorrhage. The use of intraventricular thrombolysis for drug-induced IVH has not previously been reported, although it has been shown to be a safe and potentially beneficial intervention.",

keywords = "Intraventricular hemorrhage, Sympathomimetics, Thrombolysis, Urokinase",

author = "Ziai, {Wendy C.} and Antigone Triantaphyllopoulou and Razumovsky, {Alexander Y.} and Hanley, {Daniel F.}",

note = "Funding Information: Supported in part by the Eleanor Naylor Dana Fellowship (D.F.H. and W.C.Z.), NIH/NINDS 1RO1 NS 24282-08 (D.F.H.), Grant FD-R-001693-01-1 from the Food and Drug Administration Orphan Products Development Agency (D.F.H.), and the France Merrick Foundation Grant (D.F.H.). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2003",

doi = "10.1016/j.jstrokecerebrovasdis.2003.09.011",

language = "English (US)",

volume = "12",

pages = "276--279",

journal = "Journal of Stroke and Cerebrovascular Diseases",

issn = "1052-3057",

publisher = "W.B. Saunders Ltd",

number = "6",

}

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T1 - Treatment of Sympathomimetic Induced Intraventricular Hemorrhage with Intraventricular Urokinase

AU - Ziai, Wendy C.

AU - Triantaphyllopoulou, Antigone

AU - Razumovsky, Alexander Y.

AU - Hanley, Daniel F.

N1 - Funding Information: Supported in part by the Eleanor Naylor Dana Fellowship (D.F.H. and W.C.Z.), NIH/NINDS 1RO1 NS 24282-08 (D.F.H.), Grant FD-R-001693-01-1 from the Food and Drug Administration Orphan Products Development Agency (D.F.H.), and the France Merrick Foundation Grant (D.F.H.). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2003

Y1 - 2003

N2 - Intraventricular hemorrhage (IVH) occurred in a 32-year-old man following the use of both ephedrine and pseudoephedrine. Cerebral angiography and transcranial Doppler studies showed changes suggestive of vasculitis. We describe the management and investigations of a unique case of IVH. This patient was treated with ventriculostomy and intraventricular urokinase (UK). A favorable outcome was obtained with independent function at 10 weeks post hemorrhage. The use of intraventricular thrombolysis for drug-induced IVH has not previously been reported, although it has been shown to be a safe and potentially beneficial intervention.

AB - Intraventricular hemorrhage (IVH) occurred in a 32-year-old man following the use of both ephedrine and pseudoephedrine. Cerebral angiography and transcranial Doppler studies showed changes suggestive of vasculitis. We describe the management and investigations of a unique case of IVH. This patient was treated with ventriculostomy and intraventricular urokinase (UK). A favorable outcome was obtained with independent function at 10 weeks post hemorrhage. The use of intraventricular thrombolysis for drug-induced IVH has not previously been reported, although it has been shown to be a safe and potentially beneficial intervention.

KW - Intraventricular hemorrhage

KW - Sympathomimetics

KW - Thrombolysis

KW - Urokinase

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U2 - 10.1016/j.jstrokecerebrovasdis.2003.09.011

DO - 10.1016/j.jstrokecerebrovasdis.2003.09.011

M3 - Article

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AN - SCOPUS:0346725957

VL - 12

SP - 276

EP - 279

JO - Journal of Stroke and Cerebrovascular Diseases

JF - Journal of Stroke and Cerebrovascular Diseases

SN - 1052-3057

IS - 6

ER -

Treatment of Sympathomimetic Induced Intraventricular Hemorrhage with Intraventricular Urokinase

Abstract

Keywords

ASJC Scopus subject areas

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