TY - JOUR
T1 - Treatment of severe neonatal infections with cefotaxime. Efficacy and pharmacokinetics
AU - Lietman, Paul S.
AU - Kafetzis, Dmitris A.
AU - Brater, D. Craig
AU - Kapiki, Angela N.
AU - Papas, Constantine J.
AU - Dellagrammaticas, Hiraklis
AU - Papadatos, Constantine J.
PY - 1982/3
Y1 - 1982/3
N2 - We studied the pharamcokinetics and efficacy of cefotaxime in 32 neonates with severe gram-negative infections. Many of these patients had been treated unsuccessfully with combinations of antibiotics. Eighty-one percent of these were cured, 6% improved, and 13% had treatment failures; there were three deaths. Eighteen patients received cefotaxime alone; 16 were cured and two improved. These data indiate and efficacy of cefotaxime sufficient to warrant more rigorous future trials. The elimination half-life of cefotaxime ranged from 2.0±0.4 hours in term neonates more than one week of age to 5.7±0.8 hours in preterm neonates less than one week of age. A volume of distribution of approximately 0.63 L was similar for all infants irrespective of age and maturity. These kinetic data can be used in design of future therapeutic regimens in more rigidly controlled trials assessing indications for cefotaxime therapy in neonates. We recommend dosing as follows, using a dose of 25 mg/kg: every 12 hours for preterm infants less than one week of age, every 8 hours for pretern infants one to four and term nfants less than one week of age, and every 6 hours for term infants more than one week of age.
AB - We studied the pharamcokinetics and efficacy of cefotaxime in 32 neonates with severe gram-negative infections. Many of these patients had been treated unsuccessfully with combinations of antibiotics. Eighty-one percent of these were cured, 6% improved, and 13% had treatment failures; there were three deaths. Eighteen patients received cefotaxime alone; 16 were cured and two improved. These data indiate and efficacy of cefotaxime sufficient to warrant more rigorous future trials. The elimination half-life of cefotaxime ranged from 2.0±0.4 hours in term neonates more than one week of age to 5.7±0.8 hours in preterm neonates less than one week of age. A volume of distribution of approximately 0.63 L was similar for all infants irrespective of age and maturity. These kinetic data can be used in design of future therapeutic regimens in more rigidly controlled trials assessing indications for cefotaxime therapy in neonates. We recommend dosing as follows, using a dose of 25 mg/kg: every 12 hours for preterm infants less than one week of age, every 8 hours for pretern infants one to four and term nfants less than one week of age, and every 6 hours for term infants more than one week of age.
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U2 - 10.1016/S0022-3476(82)80466-6
DO - 10.1016/S0022-3476(82)80466-6
M3 - Article
C2 - 6278118
AN - SCOPUS:0020081624
SN - 0022-3476
VL - 100
SP - 483
EP - 489
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 3
ER -