Treatment of severe amblyopia with weekend atropine

Results from 2 randomized clinical trials

Michael X Repka, Raymond T. Kraker, Roy W. Beck, Eileen Birch, Susan A. Cotter, Jonathan M. Holmes, Richard W. Hertle, Darren L. Hoover, Deborah L. Klimek, Wendy Marsh-Tootle, Mitchell M. Scheiman, Donny W. Suh, David R. Weakley

Research output: Contribution to journalArticle

Abstract

Purpose: To determine the effectiveness of weekend atropine for severe amblyopia from strabismus, anisometropia, or both combined among children 3 to 12 years of age. Methods: We enrolled children into 2 prospective, randomized multicenter clinical trials of amblyopia therapy. Herein we report the results for severe amblyopia, 20/125 to 20/400. In Trial 1, 60 children 3 to 6 years of age (mean, 4.4 years) were randomized to weekend atropine plus a plano lens or weekend atropine plus full spectacle correction for the sound eye. In Trial 2, 40 children 7 to 12 years of age (mean, 9.3 years) were randomized to weekend atropine or 2 hours of daily patching. The visual acuity outcome was assessed at 18 weeks in Trial 1 and 17 weeks in Trial 2. Results: In Trial 1, visual acuity improved by an average of 4.5 lines in the atropine plus correction group (95% CI, 3.2-5.8 lines) and 5.1 lines in the atropine plus plano lens group (95% CI, 3.7-6.4 lines). In Trial 2, visual acuity improved by an average of 1.5 lines in the atropine group (95% CI, 0.5-2.5 lines) and 1.8 lines in the patching group (95% CI, 1.1-2.6 lines). Conclusions: Weekend atropine can improve visual acuity in children 3 to 12 years of age with severe amblyopia. Improvement may be greater in younger children.{A figure is presented}.

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Amblyopia
Atropine
Randomized Controlled Trials
Visual Acuity
Therapeutics
Lenses
Anisometropia
Strabismus
Multicenter Studies

ASJC Scopus subject areas

  • Ophthalmology
  • Pediatrics, Perinatology, and Child Health

Cite this

Treatment of severe amblyopia with weekend atropine : Results from 2 randomized clinical trials. / Repka, Michael X; Kraker, Raymond T.; Beck, Roy W.; Birch, Eileen; Cotter, Susan A.; Holmes, Jonathan M.; Hertle, Richard W.; Hoover, Darren L.; Klimek, Deborah L.; Marsh-Tootle, Wendy; Scheiman, Mitchell M.; Suh, Donny W.; Weakley, David R.

In: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus, Vol. 13, No. 3, 06.2009, p. 258-263.

Research output: Contribution to journalArticle

Repka, Michael X ; Kraker, Raymond T. ; Beck, Roy W. ; Birch, Eileen ; Cotter, Susan A. ; Holmes, Jonathan M. ; Hertle, Richard W. ; Hoover, Darren L. ; Klimek, Deborah L. ; Marsh-Tootle, Wendy ; Scheiman, Mitchell M. ; Suh, Donny W. ; Weakley, David R. / Treatment of severe amblyopia with weekend atropine : Results from 2 randomized clinical trials. In: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus. 2009 ; Vol. 13, No. 3. pp. 258-263.
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abstract = "Purpose: To determine the effectiveness of weekend atropine for severe amblyopia from strabismus, anisometropia, or both combined among children 3 to 12 years of age. Methods: We enrolled children into 2 prospective, randomized multicenter clinical trials of amblyopia therapy. Herein we report the results for severe amblyopia, 20/125 to 20/400. In Trial 1, 60 children 3 to 6 years of age (mean, 4.4 years) were randomized to weekend atropine plus a plano lens or weekend atropine plus full spectacle correction for the sound eye. In Trial 2, 40 children 7 to 12 years of age (mean, 9.3 years) were randomized to weekend atropine or 2 hours of daily patching. The visual acuity outcome was assessed at 18 weeks in Trial 1 and 17 weeks in Trial 2. Results: In Trial 1, visual acuity improved by an average of 4.5 lines in the atropine plus correction group (95{\%} CI, 3.2-5.8 lines) and 5.1 lines in the atropine plus plano lens group (95{\%} CI, 3.7-6.4 lines). In Trial 2, visual acuity improved by an average of 1.5 lines in the atropine group (95{\%} CI, 0.5-2.5 lines) and 1.8 lines in the patching group (95{\%} CI, 1.1-2.6 lines). Conclusions: Weekend atropine can improve visual acuity in children 3 to 12 years of age with severe amblyopia. Improvement may be greater in younger children.{A figure is presented}.",
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AU - Beck, Roy W.

AU - Birch, Eileen

AU - Cotter, Susan A.

AU - Holmes, Jonathan M.

AU - Hertle, Richard W.

AU - Hoover, Darren L.

AU - Klimek, Deborah L.

AU - Marsh-Tootle, Wendy

AU - Scheiman, Mitchell M.

AU - Suh, Donny W.

AU - Weakley, David R.

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