Treatment of seasonal and perennial rhinitis with intranasal flunisolide

P. C. Turkeltaub, Philip S. Norman, J. D. Johnson, S. Crepea

Research output: Contribution to journalArticle

Abstract

Flunisolide (F), a potent fluorinated corticosteroid or its propylene/polyethylene glycol vehicle (V) were intranasally administered to 50 patients with ragweed hayfever and 75 patients with perennial rhinitis. Each patient was randomly assigned in a double-blind manner and indistinguishable metered pump spray device containing either F or V. Each hayfever patient administered two puffs in each nostril t.i.d. Each puff of F contained 25 μg F. Hayfever and perennial rhinitis patients inhaling F demonstrated significantly lower symptom scores compared to their V controls. Skin test positive patients with perennial rhinitis inhaling F demonstrated significantly larger reductions in symptom scores and significantly greater subjective control of symptoms compared to their V controls than their skin test negative counterparts inhaling F and V. Morning plasma cortisol measured prior to and at the end of 1 month and 3 months of F revealed no significant diminution in cortisol level compared to patients inhaling V. No long-term adverse local or systemic steroid effects attributable to F were observed. Flunisolide spray is a safe and effective modality for the treatment of seasonal and perennial rhinitis.

Original languageEnglish (US)
Pages (from-to)303-311
Number of pages9
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume37
Issue number5
StatePublished - 1982

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flunisolide
Rhinitis
Inhalation
Seasonal Allergic Rhinitis
Skin Tests
Therapeutics
Hydrocortisone
Ambrosia
Propylene Glycol
Polyethylene

ASJC Scopus subject areas

  • Immunology

Cite this

Treatment of seasonal and perennial rhinitis with intranasal flunisolide. / Turkeltaub, P. C.; Norman, Philip S.; Johnson, J. D.; Crepea, S.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 37, No. 5, 1982, p. 303-311.

Research output: Contribution to journalArticle

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