Treatment of refractory or relapsed adult acute leukemia by using mitoxantrone-containing regimens

M. T. Lin, Y. C. Chen, T. W. Liu, H. F. Tien, M. C. Liu, C. H. Wang, M. C. Shen, C. H. Liu

Research output: Contribution to journalArticle

Abstract

Twenty-eight adult patients with primary refractory or relapsed acute leukemia were treated. The regimens consisted of mitoxantrone plus cytosine arabinoside for 17 patients with acute non-lymphocytic leukemia (ANLL) and mitoxantrone accompanied with vincristine and prednisolone for 11 patients with acute lymphoblastic leukemia (ALL). In primary refractory patients, 1 of the 4 (25%) ANLL and 1 of the 3 (33%) ALL attained complete remission (CR). Excluding 2 patients who underwent bone marrow transplantation, 8 of the 13 (62%) relapsed ANLL and 4 of the 8 (50%) relapsed ALL achieved CR with a median duration of remission of 6.2 months and 3.8 months, respectively. Myelosuppression occurred in all treatment courses and was associated with pyrexia due to infections in 84% of the cases. Nausea, vomiting and stomatitis were mild. Abnormal liver function tests were observed in 8 (28%) patients. One patient, pretreated with 550 mg/m2 of doxorubicin, developed congestive heart failure. The results suggest that mitoxantrone is of value in the treatment of Chinese patients with refractory or relapsed acute leukemia.

Original languageEnglish (US)
Pages (from-to)1116-1122
Number of pages7
JournalJournal of the Formosan Medical Association
Volume88
Issue number11-12
StatePublished - Dec 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Lin, M. T., Chen, Y. C., Liu, T. W., Tien, H. F., Liu, M. C., Wang, C. H., Shen, M. C., & Liu, C. H. (1989). Treatment of refractory or relapsed adult acute leukemia by using mitoxantrone-containing regimens. Journal of the Formosan Medical Association, 88(11-12), 1116-1122.