Treatment of refractory intracranial hypertension with 23.4% saline

Jose Suarez, Adnan I. Qureshi, Anish Bhardwaj, Michael A. Williams, Mark S. Schnitzer, Marek A Mirski, Daniel F Hanley, John A Ulatowski

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the effect of intravenous bolus administration of 23.4% saline (8008 mOsm/L) on refractory intracranial hypertension (RIH) in patients with diverse intracranial diseases. Design: Retrospective chart review. Setting: A neurosciences intensive care unit in a university hospital. Patients: We present eight patients and a total of 20 episodes of increased intracranial pressure (ICP) resistant to standard modes of therapy. Five patients had subarachnoid hemorrhage, one patient had traumatic brain injury, one had a brain tumor, and another had spontaneous basal ganglia hemorrhage. Seven patients had intraventricular catheters, and one had a subarachnoid pressure screw placed. We monitored continuously mean ICP, serum sodium concentrations, mean arterial pressure, cerebral perfusion pressure (CPP), central venous pressure, and urine output before and after the administration of hypertonic saline (HS). Post mortem examination of the brain was performed in two patients. Intervention: Intravenous bolus administration of 30 mL of 23.4% saline. Measurements and Main Results: There was a significant (p <.05) decrease in ICP from a median of 41.5 mm Hg before HS to 17 mm Hg at 1 hr, 16 mm Hg at 2 hrs, and 14 mm Hg at 3 hrs after HS administration. In 80% of cases, ICP decreased by >50% of the pretreatment value over a duration of 21.2 ± 10.3 mins. ICP decreased to

Original languageEnglish (US)
Pages (from-to)1118-1122
Number of pages5
JournalCritical Care Medicine
Volume26
Issue number6
DOIs
StatePublished - 1998

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Intracranial Hypertension
Intracranial Pressure
Intravenous Administration
Therapeutics
Basal Ganglia Hemorrhage
Cerebrovascular Circulation
Central Venous Pressure
Subarachnoid Hemorrhage
Neurosciences
Brain Neoplasms
Intensive Care Units
Autopsy
Arterial Pressure
Catheters
Sodium
Urine
Brain
Serum

Keywords

  • Cerebral edema
  • Hypertonic solutions
  • Intracranial hypertension
  • Neurointensive care
  • Saline
  • Serum sodium

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Treatment of refractory intracranial hypertension with 23.4% saline. / Suarez, Jose; Qureshi, Adnan I.; Bhardwaj, Anish; Williams, Michael A.; Schnitzer, Mark S.; Mirski, Marek A; Hanley, Daniel F; Ulatowski, John A.

In: Critical Care Medicine, Vol. 26, No. 6, 1998, p. 1118-1122.

Research output: Contribution to journalArticle

Suarez, Jose ; Qureshi, Adnan I. ; Bhardwaj, Anish ; Williams, Michael A. ; Schnitzer, Mark S. ; Mirski, Marek A ; Hanley, Daniel F ; Ulatowski, John A. / Treatment of refractory intracranial hypertension with 23.4% saline. In: Critical Care Medicine. 1998 ; Vol. 26, No. 6. pp. 1118-1122.
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