Treatment of Primary Progressive Aphasia

Research output: Contribution to journalReview articlepeer-review

Abstract

Primary progressive aphasia (PPA) is a neurodegenerative disease that primarily affects language functions and often begins in the fifth or sixth decade of life. The devastating effects on work and home life call for the investigation of treatment alternatives. In this paper, we present a review of the literature on treatment approaches for this neurodegenerative disease. We also present new data from two intervention studies we have conducted, a behavioral one and a neuromodulatory one using transcranial direct current stimulation (tDCS) combined with written production intervention. We show that speech-language intervention improves language outcomes in individuals with PPA, and especially in the short term, tDCS augments generalization and maintenance of positive language outcomes. We also outline current issues and challenges in intervention approaches in PPA.

Original languageEnglish (US)
Article number34
JournalCurrent Treatment Options in Neurology
Volume17
Issue number8
DOIs
StatePublished - Aug 16 2015

Keywords

  • Apraxia of speech (AOS)
  • Dementia
  • Logogpenic variant PPA
  • Neurodegeneration
  • Neuromodulation
  • Non-fluent agrammatic PPA
  • Primary progressive aphasia (PPA)
  • Semantic variant PPA
  • Transcranial direct current stimulation (tDCS)

ASJC Scopus subject areas

  • Clinical Neurology

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