Treatment of Postherpetic Pain With Scrambler Therapy, a Patient-Specific Neurocutaneous Electrical Stimulation Device

Thomas J. Smith, Giuseppe Marineo

Research output: Contribution to journalArticle


Objectives: Postherpetic neuropathy (PHN) is common, severe, and often refractory to treatment. We treated 10 patients with refractory PHN using Scrambler therapy, a neurocutaneous stimulation device that delivers “nonpain” information with surface electrodes. Methods: Scrambler therapy was given as 30-minute sessions daily for 10 days. Pain was recorded before and after treatment. Two centers. Result: The average pain score rapidly diminished from 7.64 ± 1.46 at baseline to 0.42 ± 0.89 at 1 month, a 95% reduction, with continued relief at 2 and 3 months. Patients achieved maximum pain relief with less than 5 treatments. Discussion: Scrambler therapy appears to have a promising effect on PHN, with prompt and continued relief and no side effects. Further research is warranted.

Original languageEnglish (US)
Pages (from-to)812-813
Number of pages2
JournalAmerican Journal of Hospice and Palliative Medicine
Issue number5
StatePublished - May 1 2018



  • devices
  • electrical pain stimulation
  • neurocutaneous pain stimulation
  • new therapies for pain
  • pain
  • postherpetic neuropathy

ASJC Scopus subject areas

  • Medicine(all)

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