Treatment of porcine cysticercosis with albendazole

Armandoe Gonzalez, H. H. Garcia, Robert H Gilman, M. T. Lopez, C. Gavidia, J. McDonald, J. B. Pilcher, V. C W Tsang

Research output: Contribution to journalArticle

Abstract

In a randomized, controlled study, the efficacy and safety of two different schemes of albendazole therapy for treatment of porcine cysticercosis were tested. Seventeen naturally infected pigs were divided into three groups and treated per os with albendazole (50 mg/kg single dose), albendazole (30 mg/kg every day for three days), or given no treatment, respectively. Serologic responses were monitored with the enzyme-linked electroimmunotransfer blot assay. Pigs were humanely killed 12 weeks after treatment, necropsied, and the number of parasites was recorded. Scolex evagination was used to assess viability of the cysts. Both albendazole- treated groups had significant side effects (anorexia, lethargy). Only a single viable cyst was recovered from the brain of one animal after therapy in the multiple-dose group, and the single-dose therapy left 11% of the cysts viable. In contrast, more than 90% of muscle cysts were found to be viable in the untreated group. Although albendazole therapy for three days was found to be highly effective, side effects and the need for multiple doses would still prevent its widespread use.

Original languageEnglish (US)
Pages (from-to)571-574
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume53
Issue number5
StatePublished - 1995
Externally publishedYes

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Cysticercosis
Albendazole
Swine
Cysts
Lethargy
Anorexia
Therapeutics
Parasites
Safety
Muscles
Brain
Enzymes

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Gonzalez, A., Garcia, H. H., Gilman, R. H., Lopez, M. T., Gavidia, C., McDonald, J., ... Tsang, V. C. W. (1995). Treatment of porcine cysticercosis with albendazole. American Journal of Tropical Medicine and Hygiene, 53(5), 571-574.

Treatment of porcine cysticercosis with albendazole. / Gonzalez, Armandoe; Garcia, H. H.; Gilman, Robert H; Lopez, M. T.; Gavidia, C.; McDonald, J.; Pilcher, J. B.; Tsang, V. C W.

In: American Journal of Tropical Medicine and Hygiene, Vol. 53, No. 5, 1995, p. 571-574.

Research output: Contribution to journalArticle

Gonzalez, A, Garcia, HH, Gilman, RH, Lopez, MT, Gavidia, C, McDonald, J, Pilcher, JB & Tsang, VCW 1995, 'Treatment of porcine cysticercosis with albendazole', American Journal of Tropical Medicine and Hygiene, vol. 53, no. 5, pp. 571-574.
Gonzalez, Armandoe ; Garcia, H. H. ; Gilman, Robert H ; Lopez, M. T. ; Gavidia, C. ; McDonald, J. ; Pilcher, J. B. ; Tsang, V. C W. / Treatment of porcine cysticercosis with albendazole. In: American Journal of Tropical Medicine and Hygiene. 1995 ; Vol. 53, No. 5. pp. 571-574.
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