Treatment of Pneumocystis Pneumonia in AIDS

Mark W. Lambertus, Matthew Bidwell Goetz, Donald R. Forsdyke, Carmen J. Allegra, Bruce A. Chabner, Henry Masur, Walter T. Hughes

Research output: Contribution to journalLetter

Abstract

To the Editor: The use of glucocorticoids as adjunctive therapy of Pneumocystis carinii pneumonia remains a controversial subject. In his editorial (Oct. 15 issue),1 Hughes failed to address the issue of glucocorticoids as a potential therapeutic intervention, whereas Allegra et al. (Oct. 15 issue),2 in reporting their results with trimetrexate, referred to “high-dose corticosteroids” as experimental treatment of patients in whom conventional therapy fails. Discussion of any possible role for steroids as part of combination therapy seems warranted in the light of the seriousness of pneumocystis infections. Current treatment of pneumocystis pneumonia with trimethoprim–sulfamethoxazole or pentamidine yields disappointing results, with.

Original languageEnglish (US)
Pages (from-to)988-990
Number of pages3
JournalNew England Journal of Medicine
Volume318
Issue number15
DOIs
StatePublished - Apr 14 1988

ASJC Scopus subject areas

  • Medicine(all)

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    Lambertus, M. W., Goetz, M. B., Forsdyke, D. R., Allegra, C. J., Chabner, B. A., Masur, H., & Hughes, W. T. (1988). Treatment of Pneumocystis Pneumonia in AIDS. New England Journal of Medicine, 318(15), 988-990. https://doi.org/10.1056/NEJM198804143181510