TY - JOUR
T1 - Treatment of Pneumocystis carinii Pneumonitis
AU - Hughes, Walter T.
PY - 1976/9/23
Y1 - 1976/9/23
N2 - Before a satisfactory treatment became available, the outlook for patients with Pneumocystis carinii pneumonitis was bleak. This illness, unique to the compromised host, proved fatal in 50 per cent of infantile cases during European epidemics and in about 100 per cent of affected children and adults who were immunodeficient because of neoplasia, anticancer therapy, organ transplantation or congenital immune deficiency disorders. In 1958 Idy and Pdy, in Budapest, successfully treated the infection with pentamidine isethionate, a diamidine with antiprotozoal and antifungal activity. They were eventually able to reduce the mortality from infantile P. carinii pneumonitis from 50 per cent to.
AB - Before a satisfactory treatment became available, the outlook for patients with Pneumocystis carinii pneumonitis was bleak. This illness, unique to the compromised host, proved fatal in 50 per cent of infantile cases during European epidemics and in about 100 per cent of affected children and adults who were immunodeficient because of neoplasia, anticancer therapy, organ transplantation or congenital immune deficiency disorders. In 1958 Idy and Pdy, in Budapest, successfully treated the infection with pentamidine isethionate, a diamidine with antiprotozoal and antifungal activity. They were eventually able to reduce the mortality from infantile P. carinii pneumonitis from 50 per cent to.
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U2 - 10.1056/NEJM197609232951311
DO - 10.1056/NEJM197609232951311
M3 - Editorial
C2 - 1085414
AN - SCOPUS:0017314091
SN - 0028-4793
VL - 295
SP - 726
EP - 727
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 13
ER -