Treatment of neurocysticercosis: Current status and future research needs

T. E. Nash; G. Singh; A. C. White; V. Rajshekhar; J. A. Loeb; J. V. Proaño; O. M. Takayanagui; A. E. Gonzalez; J. A. Butman; C. DeGiorgio; O. H. Del Brutto; A. Delgado-Escueta; C. A.W. Evans; R. H. Gilman; S. M. Martinez; M. T. Medina; E. J. Pretell; J. Teale; H. H. Garcia

doi:10.1212/01.wnl.0000238514.51747.3a

Treatment of neurocysticercosis: Current status and future research needs

T. E. Nash, G. Singh, A. C. White, V. Rajshekhar, J. A. Loeb, J. V. Proaño, O. M. Takayanagui, A. E. Gonzalez, J. A. Butman, C. DeGiorgio, O. H. Del Brutto, A. Delgado-Escueta, C. A.W. Evans, R. H. Gilman, S. M. Martinez, M. T. Medina, E. J. Pretell, J. Teale, H. H. Garcia

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

144 Scopus citations

Abstract

Here we put forward a roadmap that summarizes important questions that need to be answered to determine more effective and safer treatments. A key concept in management of neurocysticercosis is the understanding that infection and disease due to neurocysticercosis are variable and thus different clinical approaches and treatments are required. Despite recent advances, treatments remain either suboptimal or based on poorly controlled or anecdotal experience. A better understanding of basic pathophysiologic mechanisms including parasite survival and evolution, nature of the inflammatory response, and the genesis of seizures, epilepsy, and mechanisms of anthelmintic action should lead to improved therapies.

Original language	English (US)
Pages (from-to)	1120-1127
Number of pages	8
Journal	Neurology
Volume	67
Issue number	7
DOIs	https://doi.org/10.1212/01.wnl.0000238514.51747.3a
State	Published - Oct 2006

ASJC Scopus subject areas

Clinical Neurology

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Nash, T. E., Singh, G., White, A. C., Rajshekhar, V., Loeb, J. A., Proaño, J. V., Takayanagui, O. M., Gonzalez, A. E., Butman, J. A., DeGiorgio, C., Del Brutto, O. H., Delgado-Escueta, A., Evans, C. A. W., Gilman, R. H., Martinez, S. M., Medina, M. T., Pretell, E. J., Teale, J., & Garcia, H. H. (2006). Treatment of neurocysticercosis: Current status and future research needs. Neurology, 67(7), 1120-1127. https://doi.org/10.1212/01.wnl.0000238514.51747.3a

Nash, TE, Singh, G, White, AC, Rajshekhar, V, Loeb, JA, Proaño, JV, Takayanagui, OM, Gonzalez, AE, Butman, JA, DeGiorgio, C, Del Brutto, OH, Delgado-Escueta, A, Evans, CAW , Gilman, RH, Martinez, SM, Medina, MT, Pretell, EJ, Teale, J & Garcia, HH 2006, 'Treatment of neurocysticercosis: Current status and future research needs', Neurology, vol. 67, no. 7, pp. 1120-1127. https://doi.org/10.1212/01.wnl.0000238514.51747.3a

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title = "Treatment of neurocysticercosis: Current status and future research needs",

abstract = "Here we put forward a roadmap that summarizes important questions that need to be answered to determine more effective and safer treatments. A key concept in management of neurocysticercosis is the understanding that infection and disease due to neurocysticercosis are variable and thus different clinical approaches and treatments are required. Despite recent advances, treatments remain either suboptimal or based on poorly controlled or anecdotal experience. A better understanding of basic pathophysiologic mechanisms including parasite survival and evolution, nature of the inflammatory response, and the genesis of seizures, epilepsy, and mechanisms of anthelmintic action should lead to improved therapies.",

author = "Nash, {T. E.} and G. Singh and White, {A. C.} and V. Rajshekhar and Loeb, {J. A.} and Proa{\~n}o, {J. V.} and Takayanagui, {O. M.} and Gonzalez, {A. E.} and Butman, {J. A.} and C. DeGiorgio and {Del Brutto}, {O. H.} and A. Delgado-Escueta and Evans, {C. A.W.} and Gilman, {R. H.} and Martinez, {S. M.} and Medina, {M. T.} and Pretell, {E. J.} and J. Teale and Garcia, {H. H.}",

note = "Funding Information: Supported by the Office of Rare Diseases (NIH), National Institute of Allergy and Infectious Diseases/Laboratory of Parasitic Diseases (NIH), Universidad Peruana Cayetano Heredia (Lima, Peru), and Instituto de Ciencias Neurologicas (Lima, Peru). ",

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doi = "10.1212/01.wnl.0000238514.51747.3a",

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T1 - Treatment of neurocysticercosis

T2 - Current status and future research needs

AU - Nash, T. E.

AU - Singh, G.

AU - White, A. C.

AU - Rajshekhar, V.

AU - Loeb, J. A.

AU - Proaño, J. V.

AU - Takayanagui, O. M.

AU - Gonzalez, A. E.

AU - Butman, J. A.

AU - DeGiorgio, C.

AU - Del Brutto, O. H.

AU - Delgado-Escueta, A.

AU - Evans, C. A.W.

AU - Gilman, R. H.

AU - Martinez, S. M.

AU - Medina, M. T.

AU - Pretell, E. J.

AU - Teale, J.

AU - Garcia, H. H.

N1 - Funding Information: Supported by the Office of Rare Diseases (NIH), National Institute of Allergy and Infectious Diseases/Laboratory of Parasitic Diseases (NIH), Universidad Peruana Cayetano Heredia (Lima, Peru), and Instituto de Ciencias Neurologicas (Lima, Peru).

PY - 2006/10

Y1 - 2006/10

N2 - Here we put forward a roadmap that summarizes important questions that need to be answered to determine more effective and safer treatments. A key concept in management of neurocysticercosis is the understanding that infection and disease due to neurocysticercosis are variable and thus different clinical approaches and treatments are required. Despite recent advances, treatments remain either suboptimal or based on poorly controlled or anecdotal experience. A better understanding of basic pathophysiologic mechanisms including parasite survival and evolution, nature of the inflammatory response, and the genesis of seizures, epilepsy, and mechanisms of anthelmintic action should lead to improved therapies.

AB - Here we put forward a roadmap that summarizes important questions that need to be answered to determine more effective and safer treatments. A key concept in management of neurocysticercosis is the understanding that infection and disease due to neurocysticercosis are variable and thus different clinical approaches and treatments are required. Despite recent advances, treatments remain either suboptimal or based on poorly controlled or anecdotal experience. A better understanding of basic pathophysiologic mechanisms including parasite survival and evolution, nature of the inflammatory response, and the genesis of seizures, epilepsy, and mechanisms of anthelmintic action should lead to improved therapies.

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Treatment of neurocysticercosis: Current status and future research needs

Abstract

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