Treatment of malignant ventricular arrhythmias with the automatic implantable cardioverter defibrillator

A. D. Slater, I. Singer, C. S. Stavens, C. Zee-Cheng, B. L. Ganzel, J. Kupersmith, Constantine Mavroudis, L. A. Gray

Research output: Contribution to journalArticle


Twenty-eight patients with malignant ventricular arrhythmias were treated with the automatic implantable cardioverter-defibrillator (AICD) in a 14-month period. Thirteen patients were resuscitated from a ventricular fibrillation (VF) episode. Fifteen patients presented with ventricular tachycardia (VT) refractory to medical therapy. The etiology was coronary artery disease in 23 of 28 patients (82%), dilated cardiomyopathy in 2 of 28 patients (7%), sarcoidosis in 2 of 28 patients, and 1 patient in 28 had lupus erythematosis. The mean left ventricular ejection fraction was 29%. A total of 27 of 28 patients (96%) patients had inducible ventricular tachycardia using programmed stimulation. The patients considered for AICD implant failed a mean of 3.6 antiarrhythmic drugs. Rate counting and defibrillating leads were inserted through a lateral thoracotomy in 17 patients and a mediansternotomy incision in 11 patients in conjunction with another cardiac procedure in 10 patients. The generators were positioned in a subcutaneous pocket beneath the left costal margin. There were no operative deaths. The mean follow-up was 6.7 months (range 1 to 14) with no VT/VF deaths in patients with defibrillators. The study demonstrated that AICD is an effective device for prevention of sudden cardiac death.

Original languageEnglish (US)
Pages (from-to)635-641
Number of pages7
JournalAnnals of Surgery
Issue number5
StatePublished - Jan 1 1989
Externally publishedYes


ASJC Scopus subject areas

  • Surgery

Cite this

Slater, A. D., Singer, I., Stavens, C. S., Zee-Cheng, C., Ganzel, B. L., Kupersmith, J., Mavroudis, C., & Gray, L. A. (1989). Treatment of malignant ventricular arrhythmias with the automatic implantable cardioverter defibrillator. Annals of Surgery, 209(5), 635-641.