Treatment of infantile spasms

Philip J. Overby, Eric H. Kossoff

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Infantile spasms are associated with a diverse range of conditions, and treatment options are available. However, outcomes remain generally poor, particularly for those with symptomatic etiologies. First-Line therapy is considered to be hormonal (adrenocorticotropic hormone; ACTH), which some evidence suggests is more effective when started early. However, side effects may place limits on its use acutely and long-term. There is additional evidence for vigabatrin, specifically for infantile spasms secondary to tuberous sclerosis complex. In refractory cases, candidacy for surgical management should be explored, along with new-generation anticonvulsants (eg, topiramate, zonisamide) and the ketogenic diet. There is urgent need for further treatment trials comparing anticonvulsants with ACTH and a satisfactory animal model for the study of spasms.

Original languageEnglish (US)
Pages (from-to)457-464
Number of pages8
JournalCurrent Treatment Options in Neurology
Issue number6
StatePublished - Nov 2006

ASJC Scopus subject areas

  • Clinical Neurology


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