TY - JOUR
T1 - Treatment of hemophilus influenzae meningitis
T2 - A comparison of chloramphenicol and tetracycline
AU - Spies, Harold W.
AU - Nelson, Kenrad E.
AU - Levin, Stuart
AU - Lepper, Mark H.
PY - 1972/5
Y1 - 1972/5
N2 - A study was done to compare the efficacy of chloramphenicol and tetracycline for the treatment of meningitis due to Hemophilus influenzae. Alternate patients with this disease were treated with one or the other of these drugs given in daily doses of 50 mg/kg at intervals by the intravenous route. In 325 patients studied, no significant differences between the two groups could be detected with respect to rates of mortality and acute complications, speed of defervescence, or rapidity of clinical recovery. Although ampicillin is the best single drug for the initial treatment of bacterial meningitis because of its broad efficacy and relative nontoxicity, our data suggest that either chloramphenicol or tetracycline could also be used for the treatment of meningitis due to H. influenzae when ampicillin is contraindicated because of allergic reactions or drug failure or for other reasons.
AB - A study was done to compare the efficacy of chloramphenicol and tetracycline for the treatment of meningitis due to Hemophilus influenzae. Alternate patients with this disease were treated with one or the other of these drugs given in daily doses of 50 mg/kg at intervals by the intravenous route. In 325 patients studied, no significant differences between the two groups could be detected with respect to rates of mortality and acute complications, speed of defervescence, or rapidity of clinical recovery. Although ampicillin is the best single drug for the initial treatment of bacterial meningitis because of its broad efficacy and relative nontoxicity, our data suggest that either chloramphenicol or tetracycline could also be used for the treatment of meningitis due to H. influenzae when ampicillin is contraindicated because of allergic reactions or drug failure or for other reasons.
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U2 - 10.1093/infdis/125.5.459
DO - 10.1093/infdis/125.5.459
M3 - Article
C2 - 4537156
AN - SCOPUS:0015332639
SN - 0022-1899
VL - 125
SP - 459
EP - 465
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -