TY - JOUR
T1 - Treatment of Gonorrhea
T2 - Comparison of Penicillin G Procaine, Doxycycline, Spectinomycin, and Ampicillin
AU - Judson, Franklyn N.
AU - Allaman, Jane
AU - Dans, Peter E.
PY - 1974/11/4
Y1 - 1974/11/4
N2 - Penicillin G procaine with probenecid, or doxycycline, or spectinomycin, or ampicillin with probenecid were used in the treatment of 1,238 men and women with gonorrhea. Of these, 718 returned for reculture. Recurrences of this disease in men as demonstrated by positive culture were as follows: after penicillin G procaine with probenecid therapy, 10%; doxycycline, 15%; spectinomycin, 10%; and ampicillin with probenecid, 10%. Recurrences in women were 1%, 4%, 2%, and 5%, respectively. Most recurrences in men were probably caused by reinfection. Comparison of strains isolated during 1971 with strains from 1973 did not indicate a trend toward increasing resistance. A strong correlation between resistance to penicillin G procaine and resistance to doxycycline and spectinomycin was shown for 83 randomly selected strains.
AB - Penicillin G procaine with probenecid, or doxycycline, or spectinomycin, or ampicillin with probenecid were used in the treatment of 1,238 men and women with gonorrhea. Of these, 718 returned for reculture. Recurrences of this disease in men as demonstrated by positive culture were as follows: after penicillin G procaine with probenecid therapy, 10%; doxycycline, 15%; spectinomycin, 10%; and ampicillin with probenecid, 10%. Recurrences in women were 1%, 4%, 2%, and 5%, respectively. Most recurrences in men were probably caused by reinfection. Comparison of strains isolated during 1971 with strains from 1973 did not indicate a trend toward increasing resistance. A strong correlation between resistance to penicillin G procaine and resistance to doxycycline and spectinomycin was shown for 83 randomly selected strains.
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U2 - 10.1001/jama.1974.03240050033021
DO - 10.1001/jama.1974.03240050033021
M3 - Article
C2 - 4278357
AN - SCOPUS:0016245411
VL - 230
SP - 705
EP - 708
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0098-7484
IS - 5
ER -