Treatment of giant-cell tumor of the pelvis

B. K S Sanjay, F. J. Frassica, Deborah Frassica, K. K. Unni, R. A. McLeod, F. H. Sim

Research output: Contribution to journalArticle

Abstract

Nineteen patients who had a giant-cell tumor of the pelvis were managed from 1944 through 1989. Thirteen of the patients were in the third or fourth decade of life. The ilium was involved in thirteen patients; the pubis, in two; the ischium, in three; and the pubis and ischium, in one. Five patients who had an initial Stage-II (active) lesion were managed with curettage; in one of the five, a local recurrence developed at twelve months, and the other four had no evidence of disease from nine to forty-six years after the curettage. Eight patients who had a Stage-III (aggressive) lesion were managed with resection of most of the lesion followed by curettage of any remaining positive margins; four of the eight also received adjuvant irradiation. None of the eight had a local recurrence; six had no evidence of disease from eight to twenty-seven years after the operation, one died because of a metastatic post-radiation sarcoma thirteen years after the operation, and one was asymptomatic but had pulmonary metastases three years after the operation. Four patients who had a Stage-III recurrent local tumor when they were first seen were managed with hemipelvectomy, wide resection, resection and curettage, and curettage and arthroplasty (one procedure each). Three had no evidence of disease seven to twenty years after the operation and one had died because of a post-radiation metastatic osteosarcoma eight years after the operation. Two patients who had Stage-III disease were managed with external beam radiation alone. One had no evidence of disease twenty-six years later. The other had a recurrence one year later, which was treated with additional irradiation; a second recurrence was treated with curettage and bone-grafting. Twenty-eight years after the initial radiation treatment, this patient had no evidence of disease. External beam irradiation was used for a total of eight patients; a post-radiation sarcoma developed in two.

Original languageEnglish (US)
Pages (from-to)1466-1475
Number of pages10
JournalThe Journal of bone and joint surgery. American volume
Volume75
Issue number10
StatePublished - 1993
Externally publishedYes

Fingerprint

Giant Cell Tumors
Pelvis
Curettage
Radiation
Ischium
Pubic Bone
Recurrence
Therapeutics
Sarcoma
Hemipelvectomy
Ilium
Bone Transplantation
Osteosarcoma
Arthroplasty
Neoplasm Metastasis
Lung

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Sanjay, B. K. S., Frassica, F. J., Frassica, D., Unni, K. K., McLeod, R. A., & Sim, F. H. (1993). Treatment of giant-cell tumor of the pelvis. The Journal of bone and joint surgery. American volume, 75(10), 1466-1475.

Treatment of giant-cell tumor of the pelvis. / Sanjay, B. K S; Frassica, F. J.; Frassica, Deborah; Unni, K. K.; McLeod, R. A.; Sim, F. H.

In: The Journal of bone and joint surgery. American volume, Vol. 75, No. 10, 1993, p. 1466-1475.

Research output: Contribution to journalArticle

Sanjay, BKS, Frassica, FJ, Frassica, D, Unni, KK, McLeod, RA & Sim, FH 1993, 'Treatment of giant-cell tumor of the pelvis', The Journal of bone and joint surgery. American volume, vol. 75, no. 10, pp. 1466-1475.
Sanjay BKS, Frassica FJ, Frassica D, Unni KK, McLeod RA, Sim FH. Treatment of giant-cell tumor of the pelvis. The Journal of bone and joint surgery. American volume. 1993;75(10):1466-1475.
Sanjay, B. K S ; Frassica, F. J. ; Frassica, Deborah ; Unni, K. K. ; McLeod, R. A. ; Sim, F. H. / Treatment of giant-cell tumor of the pelvis. In: The Journal of bone and joint surgery. American volume. 1993 ; Vol. 75, No. 10. pp. 1466-1475.
@article{aa4434c7e539479fab66aa167d55e5e6,
title = "Treatment of giant-cell tumor of the pelvis",
abstract = "Nineteen patients who had a giant-cell tumor of the pelvis were managed from 1944 through 1989. Thirteen of the patients were in the third or fourth decade of life. The ilium was involved in thirteen patients; the pubis, in two; the ischium, in three; and the pubis and ischium, in one. Five patients who had an initial Stage-II (active) lesion were managed with curettage; in one of the five, a local recurrence developed at twelve months, and the other four had no evidence of disease from nine to forty-six years after the curettage. Eight patients who had a Stage-III (aggressive) lesion were managed with resection of most of the lesion followed by curettage of any remaining positive margins; four of the eight also received adjuvant irradiation. None of the eight had a local recurrence; six had no evidence of disease from eight to twenty-seven years after the operation, one died because of a metastatic post-radiation sarcoma thirteen years after the operation, and one was asymptomatic but had pulmonary metastases three years after the operation. Four patients who had a Stage-III recurrent local tumor when they were first seen were managed with hemipelvectomy, wide resection, resection and curettage, and curettage and arthroplasty (one procedure each). Three had no evidence of disease seven to twenty years after the operation and one had died because of a post-radiation metastatic osteosarcoma eight years after the operation. Two patients who had Stage-III disease were managed with external beam radiation alone. One had no evidence of disease twenty-six years later. The other had a recurrence one year later, which was treated with additional irradiation; a second recurrence was treated with curettage and bone-grafting. Twenty-eight years after the initial radiation treatment, this patient had no evidence of disease. External beam irradiation was used for a total of eight patients; a post-radiation sarcoma developed in two.",
author = "Sanjay, {B. K S} and Frassica, {F. J.} and Deborah Frassica and Unni, {K. K.} and McLeod, {R. A.} and Sim, {F. H.}",
year = "1993",
language = "English (US)",
volume = "75",
pages = "1466--1475",
journal = "Journal of Bone and Joint Surgery - Series A",
issn = "0021-9355",
publisher = "Journal of Bone and Joint Surgery Inc.",
number = "10",

}

TY - JOUR

T1 - Treatment of giant-cell tumor of the pelvis

AU - Sanjay, B. K S

AU - Frassica, F. J.

AU - Frassica, Deborah

AU - Unni, K. K.

AU - McLeod, R. A.

AU - Sim, F. H.

PY - 1993

Y1 - 1993

N2 - Nineteen patients who had a giant-cell tumor of the pelvis were managed from 1944 through 1989. Thirteen of the patients were in the third or fourth decade of life. The ilium was involved in thirteen patients; the pubis, in two; the ischium, in three; and the pubis and ischium, in one. Five patients who had an initial Stage-II (active) lesion were managed with curettage; in one of the five, a local recurrence developed at twelve months, and the other four had no evidence of disease from nine to forty-six years after the curettage. Eight patients who had a Stage-III (aggressive) lesion were managed with resection of most of the lesion followed by curettage of any remaining positive margins; four of the eight also received adjuvant irradiation. None of the eight had a local recurrence; six had no evidence of disease from eight to twenty-seven years after the operation, one died because of a metastatic post-radiation sarcoma thirteen years after the operation, and one was asymptomatic but had pulmonary metastases three years after the operation. Four patients who had a Stage-III recurrent local tumor when they were first seen were managed with hemipelvectomy, wide resection, resection and curettage, and curettage and arthroplasty (one procedure each). Three had no evidence of disease seven to twenty years after the operation and one had died because of a post-radiation metastatic osteosarcoma eight years after the operation. Two patients who had Stage-III disease were managed with external beam radiation alone. One had no evidence of disease twenty-six years later. The other had a recurrence one year later, which was treated with additional irradiation; a second recurrence was treated with curettage and bone-grafting. Twenty-eight years after the initial radiation treatment, this patient had no evidence of disease. External beam irradiation was used for a total of eight patients; a post-radiation sarcoma developed in two.

AB - Nineteen patients who had a giant-cell tumor of the pelvis were managed from 1944 through 1989. Thirteen of the patients were in the third or fourth decade of life. The ilium was involved in thirteen patients; the pubis, in two; the ischium, in three; and the pubis and ischium, in one. Five patients who had an initial Stage-II (active) lesion were managed with curettage; in one of the five, a local recurrence developed at twelve months, and the other four had no evidence of disease from nine to forty-six years after the curettage. Eight patients who had a Stage-III (aggressive) lesion were managed with resection of most of the lesion followed by curettage of any remaining positive margins; four of the eight also received adjuvant irradiation. None of the eight had a local recurrence; six had no evidence of disease from eight to twenty-seven years after the operation, one died because of a metastatic post-radiation sarcoma thirteen years after the operation, and one was asymptomatic but had pulmonary metastases three years after the operation. Four patients who had a Stage-III recurrent local tumor when they were first seen were managed with hemipelvectomy, wide resection, resection and curettage, and curettage and arthroplasty (one procedure each). Three had no evidence of disease seven to twenty years after the operation and one had died because of a post-radiation metastatic osteosarcoma eight years after the operation. Two patients who had Stage-III disease were managed with external beam radiation alone. One had no evidence of disease twenty-six years later. The other had a recurrence one year later, which was treated with additional irradiation; a second recurrence was treated with curettage and bone-grafting. Twenty-eight years after the initial radiation treatment, this patient had no evidence of disease. External beam irradiation was used for a total of eight patients; a post-radiation sarcoma developed in two.

UR - http://www.scopus.com/inward/record.url?scp=0027440191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027440191&partnerID=8YFLogxK

M3 - Article

VL - 75

SP - 1466

EP - 1475

JO - Journal of Bone and Joint Surgery - Series A

JF - Journal of Bone and Joint Surgery - Series A

SN - 0021-9355

IS - 10

ER -