Treatment of drug-sensitive tuberculosis in persons with HIV

Alice K. Pau, Safia Kuriakose, Kelly E. Dooley, Gary Maartens

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tuberculosis (TB) is the most common opportunistic infection and the leading cause of death in patients with human immunodeficiency virus (HIV) worldwide. Persons with advanced HIV infection and those not on antiretroviral therapy (ART) are at highest risks of morbidity and mortality. Thus, early diagnosis and treatment of both HIV and TB are keys to treatment success. Concurrent treatment of both infections can be challenging due to high pill burden, overlapping toxicities, drug interactions, adherence concerns, and the potential of immune reconstitution inflammatory syndrome. This chapter provides an overview of treatment regimens and duration of therapy for drug-susceptible TB, management of adverse drug reactions, monitoring parameters, adherence interventions, and appropriate timing for ART initiation in this patient population.

Original languageEnglish (US)
Title of host publicationHIV and Tuberculosis
Subtitle of host publicationA Formidable Alliance
PublisherSpringer International Publishing
Pages181-202
Number of pages22
ISBN (Electronic)9783030291082
ISBN (Print)9783030291075
DOIs
StatePublished - Jan 1 2019

Keywords

  • Adherence
  • Anti-tuberculosis therapy
  • Antiretroviral therapy
  • Directly observed therapy
  • Drug induced liver injury
  • HIV
  • Immune reconstitution inflammatory syndrome
  • Mortality
  • Toxicities
  • Tuberculosis

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Pau, A. K., Kuriakose, S., Dooley, K. E., & Maartens, G. (2019). Treatment of drug-sensitive tuberculosis in persons with HIV. In HIV and Tuberculosis: A Formidable Alliance (pp. 181-202). Springer International Publishing. https://doi.org/10.1007/978-3-030-29108-2_9