True physiologic addiction to diazepam has been reliably described in isolated cases by documentation of a physical withdrawal syndrome characterized by agitation, tachycardia, and diaphoresis and, rarely, hallucinations, psychosis, and seizures. Although usually occurring after prolonged use of high doses, in one case a withdrawal syndrome occuured after abrupt withdrawal of diazepam after long-term use in a usual therapeutic dose. The present report describes a case of diazepam withdrawal syndrome after long-term ingestion of extremely high doses. The case was documented and the patient effectively treated with propranolol.
ASJC Scopus subject areas
- Internal Medicine