Treatment of dermatologic connective tissue disease and autoimmune blistering disorders in pregnancy

Inbal Braunstein, Victoria Werth

Research output: Contribution to journalArticle

Abstract

Autoimmune skin disease occurs in pregnancy, and treatment is often required to control both maternal disease and fetal outcomes. Here we present the available safety data in pregnancy and lactation for medications used to treat autoimmune skin diseases, including cutaneous lupus erythematosus, dermatomyositis, morphea and systemic sclerosis, pemphigus vulgaris, pemphigus foliaceus, and pemphigoid gestationis. A PubMed search of the English-language literature using keywords, "pregnancy" "rheumatic disease," and "connective tissue disease" was performed. Relevant articles found in the search and references were included. Reasonable evidence supports the careful and cautious use of topical steroids, topical calcineurin inhibitors, systemic corticosteroids, hydroxychloroquine, and azathioprine in pregnancy. Case reports or clinical experience suggest intravenous immunoglobulin, dapsone, phototherapy, rituximab, and plasmapheresis may be safe. Several treatment options exist for autoimmune skin disease in pregnancy and lactation, and should be considered when treating these patients.

Original languageEnglish (US)
Pages (from-to)354-363
Number of pages10
JournalDermatologic Therapy
Volume26
Issue number4
DOIs
StatePublished - Jul 2013
Externally publishedYes

Fingerprint

Connective Tissue Diseases
Pregnancy
Skin Diseases
Autoimmune Diseases
Pemphigus
Lactation
Pemphigoid Gestationis
Cutaneous Lupus Erythematosus
Localized Scleroderma
Hydroxychloroquine
Fetal Diseases
Therapeutics
Dapsone
Phototherapy
Dermatomyositis
Plasmapheresis
Systemic Scleroderma
Intravenous Immunoglobulins
Azathioprine
Rheumatic Diseases

Keywords

  • Autoimmune skin disease
  • Blistering disease
  • Blistering disorders
  • Cutaneous lupus erythematosus
  • Dermatomyositis
  • Lactation
  • Morphea
  • Pemphigoid gestationis
  • Pemphigus foliaceus
  • Pemphigus vulgaris
  • Pregnancy
  • Rheumatic skin disease

ASJC Scopus subject areas

  • Dermatology

Cite this

Treatment of dermatologic connective tissue disease and autoimmune blistering disorders in pregnancy. / Braunstein, Inbal; Werth, Victoria.

In: Dermatologic Therapy, Vol. 26, No. 4, 07.2013, p. 354-363.

Research output: Contribution to journalArticle

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