Treatment of chronic active hepatitis. An analysis of three controlled trials

E. C. Wright, L. B. Seeff, P. D. Berk, A. Jones, P. H. Plotz

Research output: Contribution to journalArticle

Abstract

Three controlled trials from different parts of the world are analysed. In two trials, one of which was open and did not use placebo, prednisolone was found to reduce mortality significantly. In the third trial the patients received either placebo, azathioprine, prednisone or a combination of azathioprine and prednisone. Once again prednisone appeared to be of value. The trials are criticised in their design and it is suggested that in future trials one must take into account strict clinical parameters, define the reason for exclusion and attempt true randomization with placebo control. The only patients who appear to benefit markedly from corticosteroids are those with the characteristic picture of chronic active hepatitis who are symptomatic, who are HBsAg negative and who have severe histological abnormalities of the liver biopsies. In such cases the benefit of corticosteroids outweighs their potential toxicity.

Original languageEnglish (US)
Pages (from-to)1422-1430
Number of pages9
JournalGastroenterology
Volume73
Issue number6
StatePublished - 1977
Externally publishedYes

Fingerprint

Chronic Hepatitis
Prednisone
Placebos
Azathioprine
Adrenal Cortex Hormones
Hepatitis B Surface Antigens
Random Allocation
Prednisolone
Therapeutics
Biopsy
Mortality
Liver

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Wright, E. C., Seeff, L. B., Berk, P. D., Jones, A., & Plotz, P. H. (1977). Treatment of chronic active hepatitis. An analysis of three controlled trials. Gastroenterology, 73(6), 1422-1430.

Treatment of chronic active hepatitis. An analysis of three controlled trials. / Wright, E. C.; Seeff, L. B.; Berk, P. D.; Jones, A.; Plotz, P. H.

In: Gastroenterology, Vol. 73, No. 6, 1977, p. 1422-1430.

Research output: Contribution to journalArticle

Wright, EC, Seeff, LB, Berk, PD, Jones, A & Plotz, PH 1977, 'Treatment of chronic active hepatitis. An analysis of three controlled trials', Gastroenterology, vol. 73, no. 6, pp. 1422-1430.
Wright EC, Seeff LB, Berk PD, Jones A, Plotz PH. Treatment of chronic active hepatitis. An analysis of three controlled trials. Gastroenterology. 1977;73(6):1422-1430.
Wright, E. C. ; Seeff, L. B. ; Berk, P. D. ; Jones, A. ; Plotz, P. H. / Treatment of chronic active hepatitis. An analysis of three controlled trials. In: Gastroenterology. 1977 ; Vol. 73, No. 6. pp. 1422-1430.
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