Treatment of autoimmune disease with extracorporeal photochemotherapy

Pemphigus vulgaris - preliminary report

A. H. Rook, P. W. Heald, G. T. Nahass, W. Macey, W. K. Witmer, Gerald Sylvan Lazarus, B. V. Jegasothy

Research output: Contribution to journalArticle

Abstract

Extracorporeal photochemotherapy is a new form of immunotherapy which involves the extracorporeal photoinactivation of peripheral blood cells by 8-methoxypsoralen in the presence of ultraviolet A irradiation, followed by readministration of the cells. To explore the efficacy of this therapy in the treatment of autoimmune disease, four patients with a lengthy history of corticosteroid and immunosuppressive drug-resistant pemphigus vulgaris were initiated on extracorporeal photochemotherapy. Three patients experienced a complete remission in cutaneous disease expression, permitting discontinuation of medications in two and a substantial decrease in the third. Significant reductions in serum antiepidermal cell antibody titers occurred in all four patients. The treatments were well tolerated without the occurrence of adverse events. These results in a small number of patients suggest that extracorporeal photochemotherapy may prove to be a useful tool in the treatment of aggressive autoimmune disease.

Original languageEnglish (US)
Pages (from-to)647-652
Number of pages6
JournalYale Journal of Biology and Medicine
Volume62
Issue number6
StatePublished - 1989
Externally publishedYes

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Photopheresis
Pemphigus
Autoimmune Diseases
Methoxsalen
Immunosuppressive Agents
Adrenal Cortex Hormones
Blood
Therapeutics
Cells
Skin Diseases
Irradiation
Immunotherapy
Blood Cells
Antibodies
Pharmaceutical Preparations
Serum

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rook, A. H., Heald, P. W., Nahass, G. T., Macey, W., Witmer, W. K., Lazarus, G. S., & Jegasothy, B. V. (1989). Treatment of autoimmune disease with extracorporeal photochemotherapy: Pemphigus vulgaris - preliminary report. Yale Journal of Biology and Medicine, 62(6), 647-652.

Treatment of autoimmune disease with extracorporeal photochemotherapy : Pemphigus vulgaris - preliminary report. / Rook, A. H.; Heald, P. W.; Nahass, G. T.; Macey, W.; Witmer, W. K.; Lazarus, Gerald Sylvan; Jegasothy, B. V.

In: Yale Journal of Biology and Medicine, Vol. 62, No. 6, 1989, p. 647-652.

Research output: Contribution to journalArticle

Rook, AH, Heald, PW, Nahass, GT, Macey, W, Witmer, WK, Lazarus, GS & Jegasothy, BV 1989, 'Treatment of autoimmune disease with extracorporeal photochemotherapy: Pemphigus vulgaris - preliminary report', Yale Journal of Biology and Medicine, vol. 62, no. 6, pp. 647-652.
Rook, A. H. ; Heald, P. W. ; Nahass, G. T. ; Macey, W. ; Witmer, W. K. ; Lazarus, Gerald Sylvan ; Jegasothy, B. V. / Treatment of autoimmune disease with extracorporeal photochemotherapy : Pemphigus vulgaris - preliminary report. In: Yale Journal of Biology and Medicine. 1989 ; Vol. 62, No. 6. pp. 647-652.
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