TY - JOUR
T1 - Treatment of Aspiration Pneumonia and Primary Lung Abscess
T2 - Penicillin G vs Clindamycin
AU - Bartlett, John G.
AU - Gorbach, Sherwood L.
AU - Bartlett, John G.
AU - Gorbach, Sherwood L.
AU - Bartlett, John G.
AU - Bartlett, John G.
PY - 1975/12/1
Y1 - 1975/12/1
N2 - Aspiration pneumonitis and lung abscess generally involve anaerobic bacteria, which normally colonize the upper respiratory passages. The therapeutic response of these infections to parenteral penicillin G (49 patients) and parenteral clindamycin (35 patients) was compared to determine relative efficacy. No difference was discerned between these two agents in terms of time required for defervescence, roentgenographic clearing, and ultimate outcome. Seven patients with infections including Bacteroides fragilis were treated with penicillin G, and all responded well. These data indicate that penicillin G is the preferred agent for pulmonary infections involving anaerobic bacteria. Clindamycin is a suitable alternative for patients in whom penicillin G is contraindicated.
AB - Aspiration pneumonitis and lung abscess generally involve anaerobic bacteria, which normally colonize the upper respiratory passages. The therapeutic response of these infections to parenteral penicillin G (49 patients) and parenteral clindamycin (35 patients) was compared to determine relative efficacy. No difference was discerned between these two agents in terms of time required for defervescence, roentgenographic clearing, and ultimate outcome. Seven patients with infections including Bacteroides fragilis were treated with penicillin G, and all responded well. These data indicate that penicillin G is the preferred agent for pulmonary infections involving anaerobic bacteria. Clindamycin is a suitable alternative for patients in whom penicillin G is contraindicated.
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U2 - 10.1001/jama.1975.03260220039016
DO - 10.1001/jama.1975.03260220039016
M3 - Article
C2 - 1041750
AN - SCOPUS:0016625481
SN - 0098-7484
VL - 234
SP - 935
EP - 937
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 9
ER -