Treatment of ARDS

Roy G. Brower, Lorraine B. Ware, Yves Berthiaume, Michael A. Matthay

Research output: Contribution to journalReview article

Abstract

Improved understanding of the pathogenesis of acute lung injury (ALI)/ARDS has led to important advances in the treatment of ALI/ARDS, particularly in the area of ventilator-associated lung injury. Standard supportive care for ALI/ARDS should now include a protective ventilatory strategy with low tidal volume ventilation by the protocol developed by the National Institutes of Health ARDS Network. Further refinements of the protocol for mechanical ventilation will occur as current and future clinical trials are completed. In addition, novel modes of mechanical ventilation are being studied and may augment standard therapy in the future. Although results of anti-inflammatory strategies have been disappointing in clinical trials, further trials are underway to test the efficacy of late corticosteroids and other approaches to modulation of inflammation in ALI/ARDS.

Original languageEnglish (US)
Article number35546
Pages (from-to)1347-1367
Number of pages21
JournalCHEST
Volume120
Issue number4
DOIs
StatePublished - Jan 1 2001

Keywords

  • Acute lung injury
  • Mechanical ventilation
  • Pulmonary edema
  • Ventilator-associated lung injury

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Brower, R. G., Ware, L. B., Berthiaume, Y., & Matthay, M. A. (2001). Treatment of ARDS. CHEST, 120(4), 1347-1367. [35546]. https://doi.org/10.1378/chest.120.4.1347