Abstract
Despite numerous attempts to increase the neutrophil count of infants with alloimmune neonatal neutropenia, no therapy has been consistently effective. We describe two infants with alloimmune neutropenia who had a rapid and prolonged increase in neutrophil number after treatment with granulocyte colony-stimulating factor (G-CSF). Patient 1 had antibody directed against the neutrophil antigen NA2. He received three daily doses of G-CSF, and within 2 days his neutrophil count increased from 0.350 × 109 to 3.584 × 109/L (350 to 3584/ mm3). Despite cessation of treatment the neutrophil count remained in the normal range. Patient 2 had antibody to the neutrophil antigen NA1, and received six daily doses of G-CSF. Within 4 days his neutrophil count increased from 0.477 × 109 to 4.320 × 109/L (477 to 4320/mm3) and remained in the normal range for 11 days after the last dose of G-CSF. We recommend that treatment with G-CSF be considered for selected infants with alloimmune neutropenia. (J PEDIATR 1994;125:948-51).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 948-951 |
| Number of pages | 4 |
| Journal | The Journal of pediatrics |
| Volume | 125 |
| Issue number | 6 PART 1 |
| DOIs | |
| State | Published - Dec 1994 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health