Treatment of alloimmune neonatal neutropenia with granulocyte colony-stimulating factor

Maureen M. Gilmore, David F. Stroncek, David N. Korones

Research output: Contribution to journalArticle

Abstract

Despite numerous attempts to increase the neutrophil count of infants with alloimmune neonatal neutropenia, no therapy has been consistently effective. We describe two infants with alloimmune neutropenia who had a rapid and prolonged increase in neutrophil number after treatment with granulocyte colony-stimulating factor (G-CSF). Patient 1 had antibody directed against the neutrophil antigen NA2. He received three daily doses of G-CSF, and within 2 days his neutrophil count increased from 0.350 × 109 to 3.584 × 109/L (350 to 3584/ mm3). Despite cessation of treatment the neutrophil count remained in the normal range. Patient 2 had antibody to the neutrophil antigen NA1, and received six daily doses of G-CSF. Within 4 days his neutrophil count increased from 0.477 × 109 to 4.320 × 109/L (477 to 4320/mm3) and remained in the normal range for 11 days after the last dose of G-CSF. We recommend that treatment with G-CSF be considered for selected infants with alloimmune neutropenia. (J PEDIATR 1994;125:948-51).

Original languageEnglish (US)
Pages (from-to)948-951
Number of pages4
JournalThe Journal of pediatrics
Volume125
Issue number6 PART 1
DOIs
StatePublished - Dec 1994
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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