Treatment of alcoholic liver disease

Research output: Contribution to journalArticle

Abstract

The treatment of alcoholic liver disease at present consists of abstinence from alcohol, bed rest, and dietary intake or administration of adequate amounts of calories and protein. Besides corticosteroids, which have been shown to improve hospital survival in severely ill patients with alcoholic hepatitis and liver transplantation in advanced cirrhosis, no successful specific therapy is available for alcoholic liver disease. Potential new therapeutic approaches include: (1) Treatment with specific dietary supplements such as polyunsaturated lecithin, which in baboons prevented the progression of the early stages of pericentral and interstitial fibrosis to septal fibrosis and cirrhosis;69 (2) antagonists to cytokines or antibodies to cytokine receptors for cytokines that have been shown to enhance hepatocellular necrosis or fibrosis; (3) substances that block pathways of oxygen radical formation or increase their metabolism or binding to form nonharmful compounds; (4) inhibition of collagen synthesis by proline analogues that increase intracellular collagen degradation or increase in collagen degradation by stimulation of collagenase or by insertion of exogenous DNA encoding amino or carboxyterminal peptides of procollagen into hepatocytes;70 and (5) stimulation of hepatic regeneration and recovery from alcohol-inducer liver injury.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalSeminars in Liver Disease
Volume13
Issue number2
StatePublished - May 1993

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Alcoholic Liver Diseases
Fibrosis
Collagen
Alcohol Abstinence
Cytokines
Alcoholic Hepatitis
Therapeutics
Procollagen
Bed Rest
Cytokine Receptors
Lecithins
Papio
Liver
Collagenases
Dietary Supplements
Proline
Liver Transplantation
Regeneration
Hepatocytes
Reactive Oxygen Species

ASJC Scopus subject areas

  • Hepatology

Cite this

Treatment of alcoholic liver disease. / Mezey, Esteban.

In: Seminars in Liver Disease, Vol. 13, No. 2, 05.1993, p. 210-216.

Research output: Contribution to journalArticle

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