Treatment of advanced ovarian carcinoma with a combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil (Hexa-CAF) in patients with and without previous treatment

J. P. Neijt, A. C M van Lindert, C. P J Vendrik, K. J. Roozendaal, A. Struyvenberg, H. M. Pinedo

Research output: Contribution to journalArticle

Abstract

Forty patients with stage III or IV epithelial ovarian tumors were treated with a combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil. Fourteen of 37 evaluable patients had received previous treatment. Three of these 14 previously treated patients responded; no complete remissions were achieved and more severe toxicity was seen compared with the 23 previously untreated patients. In the latter group of patients, seven partial remissions and five complete remissions documented by peritoneoscopy and laparotomy were achieved. It is concluded that the combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil is not useful as second-line chemotherapy but can be considered suitable for remission induction in previously untreated patients.

Original languageEnglish (US)
Pages (from-to)323-326
Number of pages4
JournalCancer Treatment Reports
Volume64
Issue number2-3
StatePublished - 1980
Externally publishedYes

Fingerprint

Altretamine
Methotrexate
Fluorouracil
Cyclophosphamide
Carcinoma
Therapeutics
Remission Induction
Laparoscopy
Laparotomy
Drug Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Treatment of advanced ovarian carcinoma with a combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil (Hexa-CAF) in patients with and without previous treatment. / Neijt, J. P.; van Lindert, A. C M; Vendrik, C. P J; Roozendaal, K. J.; Struyvenberg, A.; Pinedo, H. M.

In: Cancer Treatment Reports, Vol. 64, No. 2-3, 1980, p. 323-326.

Research output: Contribution to journalArticle

Neijt, J. P. ; van Lindert, A. C M ; Vendrik, C. P J ; Roozendaal, K. J. ; Struyvenberg, A. ; Pinedo, H. M. / Treatment of advanced ovarian carcinoma with a combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil (Hexa-CAF) in patients with and without previous treatment. In: Cancer Treatment Reports. 1980 ; Vol. 64, No. 2-3. pp. 323-326.
@article{7954bba8aa8b482dbcdca96095d04400,
title = "Treatment of advanced ovarian carcinoma with a combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil (Hexa-CAF) in patients with and without previous treatment",
abstract = "Forty patients with stage III or IV epithelial ovarian tumors were treated with a combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil. Fourteen of 37 evaluable patients had received previous treatment. Three of these 14 previously treated patients responded; no complete remissions were achieved and more severe toxicity was seen compared with the 23 previously untreated patients. In the latter group of patients, seven partial remissions and five complete remissions documented by peritoneoscopy and laparotomy were achieved. It is concluded that the combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil is not useful as second-line chemotherapy but can be considered suitable for remission induction in previously untreated patients.",
author = "Neijt, {J. P.} and {van Lindert}, {A. C M} and Vendrik, {C. P J} and Roozendaal, {K. J.} and A. Struyvenberg and Pinedo, {H. M.}",
year = "1980",
language = "English (US)",
volume = "64",
pages = "323--326",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "2-3",

}

TY - JOUR

T1 - Treatment of advanced ovarian carcinoma with a combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil (Hexa-CAF) in patients with and without previous treatment

AU - Neijt, J. P.

AU - van Lindert, A. C M

AU - Vendrik, C. P J

AU - Roozendaal, K. J.

AU - Struyvenberg, A.

AU - Pinedo, H. M.

PY - 1980

Y1 - 1980

N2 - Forty patients with stage III or IV epithelial ovarian tumors were treated with a combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil. Fourteen of 37 evaluable patients had received previous treatment. Three of these 14 previously treated patients responded; no complete remissions were achieved and more severe toxicity was seen compared with the 23 previously untreated patients. In the latter group of patients, seven partial remissions and five complete remissions documented by peritoneoscopy and laparotomy were achieved. It is concluded that the combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil is not useful as second-line chemotherapy but can be considered suitable for remission induction in previously untreated patients.

AB - Forty patients with stage III or IV epithelial ovarian tumors were treated with a combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil. Fourteen of 37 evaluable patients had received previous treatment. Three of these 14 previously treated patients responded; no complete remissions were achieved and more severe toxicity was seen compared with the 23 previously untreated patients. In the latter group of patients, seven partial remissions and five complete remissions documented by peritoneoscopy and laparotomy were achieved. It is concluded that the combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil is not useful as second-line chemotherapy but can be considered suitable for remission induction in previously untreated patients.

UR - http://www.scopus.com/inward/record.url?scp=0018872138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018872138&partnerID=8YFLogxK

M3 - Article

C2 - 6773656

AN - SCOPUS:0018872138

VL - 64

SP - 323

EP - 326

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 2-3

ER -