Treatment Failures With Whole-Body Extract Therapy of Insect Sting Allergy

David B K Golden, John Langlois, Martin D. Valentine, Anne Kagey-Sobotka, Lawrence M. Lichtenstein

Research output: Contribution to journalArticle

Abstract

Whole-body extracts (WBEs) remain in widespread use for therapy of insect sting anaphylaxis two years after the approval of Hymenoptera venoms. We have reviewed our experience with WBEs in our patient population. Of 250 patients who received WBE, 115 had subsequent stings. Systemic allergic reactions occurred in 65%, large local reactions in 23%, and no reaction in 12%. There was no consistent change in the severity of systemic reactions during WBE treatment. Systemic reactions occurred less commonly in younger persons or after at least two years of WBE treatment. We conclude that WBE is not effective for the prevention of allergic insect sting reactions. The natural history of the disease may account for its apparent efficacy in young people or those having prolonged WBE therapy. Venom immunotherapy is safe and rapidly effective and is the only protective treatment recommended. (JAMA 1981;246:2460-2463).

Original languageEnglish (US)
Pages (from-to)2460-2463
Number of pages4
JournalJournal of the American Medical Association
Volume246
Issue number21
DOIs
StatePublished - Nov 27 1981

Fingerprint

Insect Bites and Stings
Treatment Failure
Hypersensitivity
Venoms
Therapeutics
Hymenoptera
Anaphylaxis
Bites and Stings
Immunotherapy
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Treatment Failures With Whole-Body Extract Therapy of Insect Sting Allergy. / Golden, David B K; Langlois, John; Valentine, Martin D.; Kagey-Sobotka, Anne; Lichtenstein, Lawrence M.

In: Journal of the American Medical Association, Vol. 246, No. 21, 27.11.1981, p. 2460-2463.

Research output: Contribution to journalArticle

Golden, David B K ; Langlois, John ; Valentine, Martin D. ; Kagey-Sobotka, Anne ; Lichtenstein, Lawrence M. / Treatment Failures With Whole-Body Extract Therapy of Insect Sting Allergy. In: Journal of the American Medical Association. 1981 ; Vol. 246, No. 21. pp. 2460-2463.
@article{59be518dc05c4c72837173220955eca1,
title = "Treatment Failures With Whole-Body Extract Therapy of Insect Sting Allergy",
abstract = "Whole-body extracts (WBEs) remain in widespread use for therapy of insect sting anaphylaxis two years after the approval of Hymenoptera venoms. We have reviewed our experience with WBEs in our patient population. Of 250 patients who received WBE, 115 had subsequent stings. Systemic allergic reactions occurred in 65{\%}, large local reactions in 23{\%}, and no reaction in 12{\%}. There was no consistent change in the severity of systemic reactions during WBE treatment. Systemic reactions occurred less commonly in younger persons or after at least two years of WBE treatment. We conclude that WBE is not effective for the prevention of allergic insect sting reactions. The natural history of the disease may account for its apparent efficacy in young people or those having prolonged WBE therapy. Venom immunotherapy is safe and rapidly effective and is the only protective treatment recommended. (JAMA 1981;246:2460-2463).",
author = "Golden, {David B K} and John Langlois and Valentine, {Martin D.} and Anne Kagey-Sobotka and Lichtenstein, {Lawrence M.}",
year = "1981",
month = "11",
day = "27",
doi = "10.1001/jama.1981.03320210026018",
language = "English (US)",
volume = "246",
pages = "2460--2463",
journal = "JAMA - Journal of the American Medical Association",
issn = "0098-7484",
publisher = "American Medical Association",
number = "21",

}

TY - JOUR

T1 - Treatment Failures With Whole-Body Extract Therapy of Insect Sting Allergy

AU - Golden, David B K

AU - Langlois, John

AU - Valentine, Martin D.

AU - Kagey-Sobotka, Anne

AU - Lichtenstein, Lawrence M.

PY - 1981/11/27

Y1 - 1981/11/27

N2 - Whole-body extracts (WBEs) remain in widespread use for therapy of insect sting anaphylaxis two years after the approval of Hymenoptera venoms. We have reviewed our experience with WBEs in our patient population. Of 250 patients who received WBE, 115 had subsequent stings. Systemic allergic reactions occurred in 65%, large local reactions in 23%, and no reaction in 12%. There was no consistent change in the severity of systemic reactions during WBE treatment. Systemic reactions occurred less commonly in younger persons or after at least two years of WBE treatment. We conclude that WBE is not effective for the prevention of allergic insect sting reactions. The natural history of the disease may account for its apparent efficacy in young people or those having prolonged WBE therapy. Venom immunotherapy is safe and rapidly effective and is the only protective treatment recommended. (JAMA 1981;246:2460-2463).

AB - Whole-body extracts (WBEs) remain in widespread use for therapy of insect sting anaphylaxis two years after the approval of Hymenoptera venoms. We have reviewed our experience with WBEs in our patient population. Of 250 patients who received WBE, 115 had subsequent stings. Systemic allergic reactions occurred in 65%, large local reactions in 23%, and no reaction in 12%. There was no consistent change in the severity of systemic reactions during WBE treatment. Systemic reactions occurred less commonly in younger persons or after at least two years of WBE treatment. We conclude that WBE is not effective for the prevention of allergic insect sting reactions. The natural history of the disease may account for its apparent efficacy in young people or those having prolonged WBE therapy. Venom immunotherapy is safe and rapidly effective and is the only protective treatment recommended. (JAMA 1981;246:2460-2463).

UR - http://www.scopus.com/inward/record.url?scp=84943983832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943983832&partnerID=8YFLogxK

U2 - 10.1001/jama.1981.03320210026018

DO - 10.1001/jama.1981.03320210026018

M3 - Article

VL - 246

SP - 2460

EP - 2463

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0098-7484

IS - 21

ER -