Treatment decision for occipital arteriovenous malformations (AVMs) to achieve hemorrhagic control while maximizing visual preservation: Our experience and review of literature

Wuyang Yang, Jose L. Porras, Eunice Philadelphia, Jody Law, Tomas Garzon-Muvdi, Justin Caplan, Geoffrey P. Colby, Alexander Coon, Rafael J Tamargo, Judy Huang

Research output: Contribution to journalArticle

Abstract

Despite concern of hemorrhagic risk, patients with occipital AVMs are at significant risk for visual disturbances after treatment. We aim to characterize the hemorrhage risk and visual disturbance in occipital AVMs patients from our experience and literature review. We performed retrospective review of occipital AVM patients seen at our institution from 1990 to 2015. Patient characteristics were compared using multivariable logistic regression with follow-up visual disturbance as the outcome. We also systematically reviewed the PubMed database for English literature describing occipital AVMs (with exclusion of case reports). Ninety-seven patients satisfied inclusion criteria for our study. Mean age was 34.9 ± 16.4 years, with 50.5% male. Thirty-one (32.0%) presented with hemorrhage, and 32 (33.0%) presented with visual disturbance. Average AVM size was 4.0 ± 2.5 cm. Twenty-five (25.8%) were conservatively managed, 13 (13.4%) underwent surgery, and the rest were managed by radiosurgery (52.6%) or embolization (8.2%), with an obliteration rate of 38.9% in treated patients. During average follow-up of 5.4 years, 6 patients (6.7%) hemorrhaged yielding an annual hemorrhage rate of 1.2% for all patients, and 0.0% for surgically-treated patients. Thirty-seven (38.3%) patients experienced visual disturbance in some capacity, nineteen (21.1%) had de novo visual disturbance, fourteen of which were surgically treated patients (19.4%). Multivariable analysis reveals visual disturbance at presentation (p = .012) and microsurgery (p = .047) are significantly predictors of follow-up visual disturbance. While hemorrhage control remains the primary goal of AVM treatment, visual preservation in occipital AVMs is also a major concern. Recommending patients for microsurgery should be weighed carefully and individualized as it bears the highest risk of visual field disturbance despite most optimal hemorrhage control.

Original languageEnglish (US)
JournalJournal of Clinical Neuroscience
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Arteriovenous Malformations
Hemorrhage
Therapeutics
Microsurgery
Literature
Radiosurgery
Visual Fields
PubMed
Logistic Models
Databases

Keywords

  • Arteriovenous malformation
  • Occipital
  • Surgery
  • Visual disturbance

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Treatment decision for occipital arteriovenous malformations (AVMs) to achieve hemorrhagic control while maximizing visual preservation : Our experience and review of literature. / Yang, Wuyang; Porras, Jose L.; Philadelphia, Eunice; Law, Jody; Garzon-Muvdi, Tomas; Caplan, Justin; Colby, Geoffrey P.; Coon, Alexander; Tamargo, Rafael J; Huang, Judy.

In: Journal of Clinical Neuroscience, 01.01.2017.

Research output: Contribution to journalArticle

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abstract = "Despite concern of hemorrhagic risk, patients with occipital AVMs are at significant risk for visual disturbances after treatment. We aim to characterize the hemorrhage risk and visual disturbance in occipital AVMs patients from our experience and literature review. We performed retrospective review of occipital AVM patients seen at our institution from 1990 to 2015. Patient characteristics were compared using multivariable logistic regression with follow-up visual disturbance as the outcome. We also systematically reviewed the PubMed database for English literature describing occipital AVMs (with exclusion of case reports). Ninety-seven patients satisfied inclusion criteria for our study. Mean age was 34.9 ± 16.4 years, with 50.5{\%} male. Thirty-one (32.0{\%}) presented with hemorrhage, and 32 (33.0{\%}) presented with visual disturbance. Average AVM size was 4.0 ± 2.5 cm. Twenty-five (25.8{\%}) were conservatively managed, 13 (13.4{\%}) underwent surgery, and the rest were managed by radiosurgery (52.6{\%}) or embolization (8.2{\%}), with an obliteration rate of 38.9{\%} in treated patients. During average follow-up of 5.4 years, 6 patients (6.7{\%}) hemorrhaged yielding an annual hemorrhage rate of 1.2{\%} for all patients, and 0.0{\%} for surgically-treated patients. Thirty-seven (38.3{\%}) patients experienced visual disturbance in some capacity, nineteen (21.1{\%}) had de novo visual disturbance, fourteen of which were surgically treated patients (19.4{\%}). Multivariable analysis reveals visual disturbance at presentation (p = .012) and microsurgery (p = .047) are significantly predictors of follow-up visual disturbance. While hemorrhage control remains the primary goal of AVM treatment, visual preservation in occipital AVMs is also a major concern. Recommending patients for microsurgery should be weighed carefully and individualized as it bears the highest risk of visual field disturbance despite most optimal hemorrhage control.",
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