Treatment as Prevention: Characterization of partner infections in the HIV Prevention Trials Network 052 trial

Susan H. Eshleman, Sarah E. Hudelson, Andrew D. Redd, Ronald Swanstrom, San San Ou, Xinyi Cindy Zhang, Li Hua Ping, Estelle Piwowar-Manning, Stephen F. Porcella, Matthew F. Sievers, Craig A. Martens, Daniel Bruno, Elena Dukhovlinova, Marybeth McCauley, Theresa Gamble, Jessica M. Fogel, Devin Sabin, Thomas C. Quinn, Laurence Gunde, Madalitso MaliwichiNehemiah Nhando, Victor Akelo, Sikhulile Moyo, Ravindre Panchia, Nagalingeswaran Kumarasamy, Nuntisa Chotirosniramit, Marineide Gonçalves de Melo, Jose Pilotto, Beatriz Grinsztejn, Kenneth Mayer, Ying Q. Chen, James P. Hughes, Myron S. Cohen

Research output: Contribution to journalArticle

Abstract

ABSTRACT: HIV Prevention Trials Network (HPTN) 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner’s infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: four near the time of ART initiation and four after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.

Original languageEnglish (US)
JournalJournal of Acquired Immune Deficiency Syndromes
DOIs
StateAccepted/In press - Aug 16 2016

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HIV Infections
Infection
HIV
Therapeutics
Genetic Linkage
Viral Load

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Treatment as Prevention : Characterization of partner infections in the HIV Prevention Trials Network 052 trial. / Eshleman, Susan H.; Hudelson, Sarah E.; Redd, Andrew D.; Swanstrom, Ronald; Ou, San San; Zhang, Xinyi Cindy; Ping, Li Hua; Piwowar-Manning, Estelle; Porcella, Stephen F.; Sievers, Matthew F.; Martens, Craig A.; Bruno, Daniel; Dukhovlinova, Elena; McCauley, Marybeth; Gamble, Theresa; Fogel, Jessica M.; Sabin, Devin; Quinn, Thomas C.; Gunde, Laurence; Maliwichi, Madalitso; Nhando, Nehemiah; Akelo, Victor; Moyo, Sikhulile; Panchia, Ravindre; Kumarasamy, Nagalingeswaran; Chotirosniramit, Nuntisa; Gonçalves de Melo, Marineide; Pilotto, Jose; Grinsztejn, Beatriz; Mayer, Kenneth; Chen, Ying Q.; Hughes, James P.; Cohen, Myron S.

In: Journal of Acquired Immune Deficiency Syndromes, 16.08.2016.

Research output: Contribution to journalArticle

Eshleman, SH, Hudelson, SE, Redd, AD, Swanstrom, R, Ou, SS, Zhang, XC, Ping, LH, Piwowar-Manning, E, Porcella, SF, Sievers, MF, Martens, CA, Bruno, D, Dukhovlinova, E, McCauley, M, Gamble, T, Fogel, JM, Sabin, D, Quinn, TC, Gunde, L, Maliwichi, M, Nhando, N, Akelo, V, Moyo, S, Panchia, R, Kumarasamy, N, Chotirosniramit, N, Gonçalves de Melo, M, Pilotto, J, Grinsztejn, B, Mayer, K, Chen, YQ, Hughes, JP & Cohen, MS 2016, 'Treatment as Prevention: Characterization of partner infections in the HIV Prevention Trials Network 052 trial', Journal of Acquired Immune Deficiency Syndromes. https://doi.org/10.1097/QAI.0000000000001158
Eshleman, Susan H. ; Hudelson, Sarah E. ; Redd, Andrew D. ; Swanstrom, Ronald ; Ou, San San ; Zhang, Xinyi Cindy ; Ping, Li Hua ; Piwowar-Manning, Estelle ; Porcella, Stephen F. ; Sievers, Matthew F. ; Martens, Craig A. ; Bruno, Daniel ; Dukhovlinova, Elena ; McCauley, Marybeth ; Gamble, Theresa ; Fogel, Jessica M. ; Sabin, Devin ; Quinn, Thomas C. ; Gunde, Laurence ; Maliwichi, Madalitso ; Nhando, Nehemiah ; Akelo, Victor ; Moyo, Sikhulile ; Panchia, Ravindre ; Kumarasamy, Nagalingeswaran ; Chotirosniramit, Nuntisa ; Gonçalves de Melo, Marineide ; Pilotto, Jose ; Grinsztejn, Beatriz ; Mayer, Kenneth ; Chen, Ying Q. ; Hughes, James P. ; Cohen, Myron S. / Treatment as Prevention : Characterization of partner infections in the HIV Prevention Trials Network 052 trial. In: Journal of Acquired Immune Deficiency Syndromes. 2016.
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