Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial

Susan H. Eshleman, Sarah E. Hudelson, Andrew D. Redd, Ronald Swanstrom, San San Ou, Xinyi Cindy Zhang, Li Hua Ping, Estelle Piwowar-Manning, Stephen F. Porcella, Matthew F. Sievers, Craig A. Martens, Daniel Bruno, Elena Dukhovlinova, Marybeth McCauley, Theresa Gamble, Jessica M. Fogel, Devin Sabin, Thomas C. Quinn, Laurence Gunde, Madalitso MaliwichiNehemiah Nhando, Victor Akelo, Sikhulile Moyo, Ravindre Panchia, Nagalingeswaran Kumarasamy, Nuntisa Chotirosniramit, Marineide Gonçalves De Melo, Jose Pilotto, Beatriz Grinsztejn, Kenneth Mayer, Ying Q. Chen, James P. Hughes, Myron S. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalJournal of acquired immune deficiency syndromes
Volume74
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • HIV-1
  • HPTN 052
  • linkage
  • partner
  • serodiscordant couples
  • transmission

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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