Treatment and survival outcome for molecular breast cancer subtypes in black women

Chukwuemeka U. Ihemelandu, Tammey J. Naab, Haile M. Mezghebe, Kepher H. Makambi, Suryanarayana M. Siram, Lasalle D. Leffall, Robert L. DeWitty, Wayne A. Frederick

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To analyze whether the local-regional surgical treatments (breast-conserving therapy, mastectomy) resulted in different overall survival, distant metastasis-free survival, and locoregional recurrencefree survival rates for the various molecular breast cancer subtypes. Summary Background Data: Molecular gene expression profiling has been proposed as a new classification and prognostication system for breast cancer. Current recommendation for local-regional treatment of breast cancer is based on traditional clinicopathologic variables. Methods: Retrospective analysis of 372 breast cancer cases with assessable immunohistochemical data for ER, PR, and Her-2/neu receptor status, diagnosed from 1998 to 2005. Molecular subtypes analyzed were luminal A, luminal B, basal like, and Her-2/neu. Results: No substantial difference was noted in overall survival, and locoregional recurrence rate between the local-regional treatment modalities as a function of the molecular breast cancer subtypes. The basal cell-like subtype was an independent predictor of a poorer overall survival (hazard ratio [HR] = 2.52, 95% confidence interval [CI] 1.28-4.97, P<0.01) and a shorter distant metastasis-free survival time (HR = 3.61, 95% CI 1.27-10.2, P < 0.01), and showed a tendency toward statistical significance as an independent predictor of locoregional recurrence (HR = 3.57, 95% CI 0.93-13.6, P = 0.06). Conclusions: The basal cell-like subtype is associated with a worse prognosis, a higher incidence of distant metastasis, and may be more prone to local recurrence when managed with breastconserving therapy.

Original languageEnglish (US)
Pages (from-to)463-469
Number of pages7
JournalAnnals of surgery
Volume247
Issue number3
DOIs
StatePublished - Mar 1 2008

ASJC Scopus subject areas

  • Surgery

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