Treating cancer as an infectious disease-viral antigens as novel targets for treatment and potential prevention of tumors of viral etiology

Xing Guo Wang, Ekaterina Revskaya, Ruth A. Bryan, Howard D. Strickler, Robert D. Burk, Arturo Casadevall, Ekaterina Dadachova

Research output: Contribution to journalArticle

Abstract

Background. Nearly 20% of human cancers worldwide have an infectious etiology with the most prominent examples being hepatitis B and C virus-associated hepatocellular carcinoma and human papilloma virus-associated cervical cancer. There is an urgent need to find new approaches to treatment and prevention of virus-associated cancers. Metholdology/principal Findings. Viral antigens have not been previously considered as targets for treatment or prevention of virus-associated cancers. We hypothesized that it was possible to treat experimental HPV16-associated cervical cance. (CC) and Hipatitis B-associated hepatocellular carcinoma (HCC) by targeting viral antigens expressed on cancer cells with radiolabeled antibodies to viral antigens. Treatment of experimental CC and HCC tumors with 188Re-labeled mAbs to E6 and HBx viral proteins, respectively resulted in significant and dose-dependent retardation of tumor growth in comparison with untreated mice or mice treated with unlabeled antibodies. Conclusions/Significance. This strategy is fundamentally different from the prior uses of radioimmunotherapy in ontology, which targeted tumor-associated human antigens and promises increased specificity and minimal toxicity of treatment. It also raises an exciting possibility to prevent virus-associated cancers in chronically infected patients by eliminating cells infected with oncogenic viruses before they transform into cancer.

Original languageEnglish (US)
Article numbere1114
JournalPLoS One
Volume2
Issue number10
DOIs
StatePublished - Oct 31 2007
Externally publishedYes

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Viral Antigens
viral antigens
Viruses
infectious diseases
Communicable Diseases
etiology
Tumors
neoplasms
Neoplasms
hepatoma
Oncogenic viruses
viruses
Hepatocellular Carcinoma
Therapeutics
Antibodies
Papillomaviridae
Viral Proteins
oncogenic viruses
Ontology
Toxicity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Treating cancer as an infectious disease-viral antigens as novel targets for treatment and potential prevention of tumors of viral etiology. / Wang, Xing Guo; Revskaya, Ekaterina; Bryan, Ruth A.; Strickler, Howard D.; Burk, Robert D.; Casadevall, Arturo; Dadachova, Ekaterina.

In: PLoS One, Vol. 2, No. 10, e1114, 31.10.2007.

Research output: Contribution to journalArticle

Wang, Xing Guo ; Revskaya, Ekaterina ; Bryan, Ruth A. ; Strickler, Howard D. ; Burk, Robert D. ; Casadevall, Arturo ; Dadachova, Ekaterina. / Treating cancer as an infectious disease-viral antigens as novel targets for treatment and potential prevention of tumors of viral etiology. In: PLoS One. 2007 ; Vol. 2, No. 10.
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AU - Burk, Robert D.

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