Treating acute pancreatitis: What's new?

Vikesh K. Singh, Robert A. Moran, Elham Afghani, Enrique De-Madaria

Research output: Contribution to journalReview article

Abstract

The medical treatment of acute pancreatitis continues to focus on supportive care, including fluid therapy, nutrition, and antibiotics, all of which will be critically reviewed. Pharmacologic agents that were previously studied were found to be ineffective likely due to a combination of their targets and flaws in trial design. Potential future pharmacologic agents, particularly those that target intracellular calcium signaling, as well as considerations for trial design will be discussed. As the incidence of acute pancreatitis continues to increase, greater efforts will be needed to prevent hospitalization, readmission and excessive imaging in order to reduce overall healthcare costs. Primary prevention continues to focus on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and secondary prevention on cholecystectomy for biliary pancreatitis as well as alcohol and smoking abstinence.

Original languageEnglish (US)
Pages (from-to)901-911
Number of pages11
JournalExpert Review of Gastroenterology and Hepatology
Volume9
Issue number7
DOIs
StatePublished - Sep 1 2015

Keywords

  • acute pancreatitis
  • clinical trials
  • drugs
  • medical therapy
  • primary prevention
  • resource utilization
  • secondary prevention

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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