Traumatic brain injury in the rat using the fluid-percussion model.

Geoffrey S.F. Ling, Eleanor Y. Lee, Audrey N. Kalehua

Research output: Contribution to journalArticlepeer-review

Abstract

Traumatic brain injury is a leading cause of death and disability, particularly among young adults. During closed head trauma, the injury process is initiated by the impact of the brain against the inner table of the calvarium. Subsequently, there is prompt initiation of a complex biochemical, cellular, and physiological injury cascade that may take days to complete. From a functional standpoint, this culminates in neurologic dysfunction and, if severe, death. This unit describes an impact-induced brain trauma model in rats which replicates nonpenetrating head injury. It does not model either penetrating or ischemic brain injuries.

Original languageEnglish (US)
Pages (from-to)Unit 9.2
JournalCurrent protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]
VolumeChapter 9
DOIs
StatePublished - Sep 2004
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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