Transverse myelitis: Pathogenesis, diagnosis and treatment

Chitra Krishnan, Adam I. Kaplin, Deepa M. Deshpande, Carlos A. Pardo, Douglas A. Kerr

Research output: Contribution to journalReview article

Abstract

Transverse Myelitis (TM) is a clinical syndrome in which an immune-mediated process causes neural injury to the spinal cord, resulting in varying degrees of weakness, sensory alterations and autonomic dysfunction. TM may exist as part of a multi-focal CNS disease (e.g. MS), multi-systemic disease (e.g. systemic lupus erythematosus), or as an isolated, idiopathic entity. In this article, we will summarize recent classification and diagnostic schemes (1), which provide a framework for the acute management of patients with TM. Additionally, we will review current concepts on the natural history, immunopathogenesis and treatment strategies for patients with TM.

Original languageEnglish (US)
Pages (from-to)1483-1499
Number of pages17
JournalFrontiers in Bioscience
Volume9
DOIs
StatePublished - Jan 1 2004

Keywords

  • Interleukin-6
  • Neuroimmunologic disorders
  • Review
  • Transverse myelitis
  • Transverse myelopathy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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