Transurethral light delivery for prostate photoacoustic imaging

Muyinatu A Lediju Bell, Xiaoyu Guo, Danny Y Song, Emad Boctor

Research output: Contribution to journalArticle

Abstract

Photoacoustic imaging has broad clinical potential to enhance prostate cancer detection and treatment, yet it is challenged by the lack of minimally invasive, deeply penetrating light delivery methods that provide sufficient visualization of targets (e.g., tumors, contrast agents, brachytherapy seeds). We constructed a sidefiring fiber prototype for transurethral photoacoustic imaging of prostates with a dual-array (linear and curvilinear) transrectal ultrasound probe. A method to calculate the surface area and, thereby, estimate the laser fluence at this fiber tip was derived, validated, applied to various design parameters, and used as an input to three-dimensional Monte Carlo simulations. Brachytherapy seeds implanted in phantom, ex vivo, and in vivo canine prostates at radial distances of 5 to 30mm from the urethra were imaged with the fiber prototype transmitting 1064 nm wavelength light with 2 to 8 mJ pulse energy. Prebeamformed images were displayed in real time at a rate of 3 to 5 frames per second to guide fiber placement and beamformed offline. A conventional delay-and-sum beamformer provided decreasing seed contrast (23 to 9 dB) with increasing urethra-to-target distance, while the shortlag spatial coherence beamformer provided improved and relatively constant seed contrast (28 to 32 dB) regardless of distance, thus improving multitarget visualization in single and combined curvilinear images acquired with the fiber rotating and the probe fixed. The proposed light delivery and beamforming methods promise to improve key prostate cancer detection and treatment strategies.

Original languageEnglish (US)
Article number036002
JournalJournal of Biomedical Optics
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2015

Fingerprint

Photoacoustic effect
delivery
Seed
seeds
Imaging techniques
fibers
Fibers
Visualization
cancer
prototypes
probes
beamforming
linear arrays
Beamforming
Contrast Media
Tumors
fluence
tumors
Ultrasonics
Wavelength

Keywords

  • biopsy guidance
  • contrast agents; in vivo
  • interventional brachytherapy
  • optoacoustic imaging
  • prostate cancer
  • side-fire fiber
  • side-looking probe

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Transurethral light delivery for prostate photoacoustic imaging. / Bell, Muyinatu A Lediju; Guo, Xiaoyu; Song, Danny Y; Boctor, Emad.

In: Journal of Biomedical Optics, Vol. 20, No. 3, 036002, 01.03.2015.

Research output: Contribution to journalArticle

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