Transport of gallocatechin gallate and catechin gallate in high-temperature-processed green tea extract from gastrointestinal tract to brain by an in vitro bio-mimic model system coupled with sequential cell cultures

Kang Hyun Jeong; Si Young Cho; Yong Deog Hong; Jin Oh Chung; Kwang Sik Kim; Soon Mi Shim

doi:10.1016/j.jff.2018.05.028

Transport of gallocatechin gallate and catechin gallate in high-temperature-processed green tea extract from gastrointestinal tract to brain by an in vitro bio-mimic model system coupled with sequential cell cultures

Kang Hyun Jeong, Si Young Cho, Yong Deog Hong, Jin Oh Chung, Kwang Sik Kim, Soon Mi Shim

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The aim of this study was to evaluate the transport of gallocatechin gallate (GCG), catechin gallate (CG) and their metabolites in high-temperature-processed green tea extract (HTP_GTE) from the gastrointestinal tract to blood-brain barrier (BBB) with an in vitro bio-mimic model system with sequential cell cultures including Caco-2, HepG2 and HBMECs. Transports from the GI to BBB, the final concentrations of GCC and CG were 18.95 ± 3.24 μM and 5.11 ± 0.83 μM, respectively. Metabolites detected in BBB after systemic circulation were identified as glucuronide or sulfate conjugated form. Results suggest that GCG, CG and their metabolites in HTP_GTE are capable of reaching the brain by oral intake of HTP_GTE, implying that HTP_GTE could be utilized as a natural functional material for the prevention of degenerative brain diseases.

Original language	English (US)
Pages (from-to)	83-90
Number of pages	8
Journal	Journal of Functional Foods
Volume	47
DOIs	https://doi.org/10.1016/j.jff.2018.05.028
State	Published - Aug 2018

Keywords

CG
GCG
In vitro bio-mimic model
Metabolite

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

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Jeong, K. H., Cho, S. Y., Hong, Y. D., Chung, J. O., Kim, K. S., & Shim, S. M. (2018). Transport of gallocatechin gallate and catechin gallate in high-temperature-processed green tea extract from gastrointestinal tract to brain by an in vitro bio-mimic model system coupled with sequential cell cultures. Journal of Functional Foods, 47, 83-90. https://doi.org/10.1016/j.jff.2018.05.028

Transport of gallocatechin gallate and catechin gallate in high-temperature-processed green tea extract from gastrointestinal tract to brain by an in vitro bio-mimic model system coupled with sequential cell cultures. / Jeong, Kang Hyun; Cho, Si Young; Hong, Yong Deog et al.
In: Journal of Functional Foods, Vol. 47, 08.2018, p. 83-90.

Research output: Contribution to journal › Article › peer-review

Jeong, KH, Cho, SY, Hong, YD, Chung, JO, Kim, KS & Shim, SM 2018, 'Transport of gallocatechin gallate and catechin gallate in high-temperature-processed green tea extract from gastrointestinal tract to brain by an in vitro bio-mimic model system coupled with sequential cell cultures', Journal of Functional Foods, vol. 47, pp. 83-90. https://doi.org/10.1016/j.jff.2018.05.028

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title = "Transport of gallocatechin gallate and catechin gallate in high-temperature-processed green tea extract from gastrointestinal tract to brain by an in vitro bio-mimic model system coupled with sequential cell cultures",

abstract = "The aim of this study was to evaluate the transport of gallocatechin gallate (GCG), catechin gallate (CG) and their metabolites in high-temperature-processed green tea extract (HTP_GTE) from the gastrointestinal tract to blood-brain barrier (BBB) with an in vitro bio-mimic model system with sequential cell cultures including Caco-2, HepG2 and HBMECs. Transports from the GI to BBB, the final concentrations of GCC and CG were 18.95 ± 3.24 μM and 5.11 ± 0.83 μM, respectively. Metabolites detected in BBB after systemic circulation were identified as glucuronide or sulfate conjugated form. Results suggest that GCG, CG and their metabolites in HTP_GTE are capable of reaching the brain by oral intake of HTP_GTE, implying that HTP_GTE could be utilized as a natural functional material for the prevention of degenerative brain diseases.",

keywords = "CG, GCG, In vitro bio-mimic model, Metabolite",

author = "Jeong, {Kang Hyun} and Cho, {Si Young} and Hong, {Yong Deog} and Chung, {Jin Oh} and Kim, {Kwang Sik} and Shim, {Soon Mi}",

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year = "2018",

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doi = "10.1016/j.jff.2018.05.028",

language = "English (US)",

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AU - Jeong, Kang Hyun

AU - Cho, Si Young

AU - Hong, Yong Deog

AU - Chung, Jin Oh

AU - Kim, Kwang Sik

AU - Shim, Soon Mi

PY - 2018/8

Y1 - 2018/8

N2 - The aim of this study was to evaluate the transport of gallocatechin gallate (GCG), catechin gallate (CG) and their metabolites in high-temperature-processed green tea extract (HTP_GTE) from the gastrointestinal tract to blood-brain barrier (BBB) with an in vitro bio-mimic model system with sequential cell cultures including Caco-2, HepG2 and HBMECs. Transports from the GI to BBB, the final concentrations of GCC and CG were 18.95 ± 3.24 μM and 5.11 ± 0.83 μM, respectively. Metabolites detected in BBB after systemic circulation were identified as glucuronide or sulfate conjugated form. Results suggest that GCG, CG and their metabolites in HTP_GTE are capable of reaching the brain by oral intake of HTP_GTE, implying that HTP_GTE could be utilized as a natural functional material for the prevention of degenerative brain diseases.

AB - The aim of this study was to evaluate the transport of gallocatechin gallate (GCG), catechin gallate (CG) and their metabolites in high-temperature-processed green tea extract (HTP_GTE) from the gastrointestinal tract to blood-brain barrier (BBB) with an in vitro bio-mimic model system with sequential cell cultures including Caco-2, HepG2 and HBMECs. Transports from the GI to BBB, the final concentrations of GCC and CG were 18.95 ± 3.24 μM and 5.11 ± 0.83 μM, respectively. Metabolites detected in BBB after systemic circulation were identified as glucuronide or sulfate conjugated form. Results suggest that GCG, CG and their metabolites in HTP_GTE are capable of reaching the brain by oral intake of HTP_GTE, implying that HTP_GTE could be utilized as a natural functional material for the prevention of degenerative brain diseases.

KW - CG

KW - GCG

KW - In vitro bio-mimic model

KW - Metabolite

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ER -

Transport of gallocatechin gallate and catechin gallate in high-temperature-processed green tea extract from gastrointestinal tract to brain by an in vitro bio-mimic model system coupled with sequential cell cultures

Abstract

Keywords

ASJC Scopus subject areas

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