Transport of Fluorescein in the Ocular Posterior Segment in Retinitis Pigmentosa

Kim S. Mallick, Ran C. Zeimer, Gerald A. Fishman, Norman P. Blair, Robert J. Anderson

Research output: Contribution to journalArticle

Abstract

The function of the blood-retinal barrier was assessed by vitreous fluorophotometry in 12 patients with various genetic types of retinitis pigmentosa and in 11 normal subjects. The measurements were corrected to minimize the effect of artifacts. We evaluated the inward penetration of fluorescein sodium across the blood-retinal barrier and determined the outward permeability coefficient for fluorescein by interpreting the data with a pharmacokinetic computer model. Patients with retinitis pigmentosa had increased inward permeability and decreased outward permeability to fluorescein in comparison with values of normal subjects.

Original languageEnglish (US)
Pages (from-to)691-696
Number of pages6
JournalArchives of ophthalmology
Volume102
Issue number5
DOIs
StatePublished - May 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Ophthalmology

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