Transport ATPases in biological systems and relationship to human disease: A brief overview

Peter L. Pedersen

Research output: Contribution to journalShort surveypeer-review

Abstract

Interest in the field of transport ATPases has grown dramatically during the past 20 years and gained considerable visibility for several reasons. First, it was shown that most transport ATPases can be lumped into only a few categories designated simply as P, V, F, and ABC types, the latter consisting of a large superfamily. Second, it has been shown that many transport ATPases have a clear relevance to human disease. Third, the field of transport ATPases has become rather advanced in the study of the reaction mechanisms and structure-function relationships associated with several of these enzymes. Finally, the Nobel committee recently recognized major accomplishments in this field of research. Here, the author provides a brief discussion of transport ATPases that are present in biological systems and their relevance or possible relevance to human disease.

Original languageEnglish (US)
Pages (from-to)327-332
Number of pages6
JournalJournal of Bioenergetics and Biomembranes
Volume34
Issue number5
DOIs
StatePublished - Oct 2002

Keywords

  • ABC transporters
  • ATP synthase
  • ATPase
  • F-type ATPase
  • Human disease
  • Ion-motive ATPases
  • P-type ATPase
  • Transport ATPase
  • V-type ATPase

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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