Transplantation tolerance: The concept and its applicability

Victor M. Dong, Karl L. Womer, Mohamed H. Sayegh

Research output: Contribution to journalArticle

Abstract

Recent advances have enabled researchers to induce tolerance in animal transplant models. Although it has been relatively easy to do so in rodents, it has been much more difficult to translate such strategies into primates. Understanding the cellular and molecular mechanisms of the alloimmune response has prompted the development of novel strategies that may obviate the need for immunosuppression in humans. Mechanisms of tolerance and promising new therapies, as well as the inherent difficulties in bringing them into clinical practice, are reviewed.

Original languageEnglish (US)
Pages (from-to)181-192
Number of pages12
JournalPediatric transplantation
Volume3
Issue number3
DOIs
StatePublished - Aug 1 1999

Keywords

  • Allorecognition
  • Costimulatory blockade
  • Rejection
  • Tolerance
  • Transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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