Transplantation: All for one and one for all-alloimmunization and polyreactivity

Robert A. Montgomery, Andrea A. Zachary

Research output: Contribution to journalArticlepeer-review

Abstract

In a new study, Porcheray et al. provide evidence that a single antibody generated by alloimmunization can recognize multiple antigens in a paradigm-changing fashion. Although these results require confirmation, the presence of polyreactive antibody may offer an explanation as to why some patients with a single sensitizing event develop a wide breadth of panel-reactive antibody.

Original languageEnglish (US)
Pages (from-to)442-443
Number of pages2
JournalNature Reviews Nephrology
Volume8
Issue number8
DOIs
StatePublished - Aug 1 2012

ASJC Scopus subject areas

  • Nephrology

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