Transplacental induction of membranous nephropathy in a neonate

Jeroen Nauta, Emile de Heer, William M. Baldwin, Fiebo J W ten Kate, Albertus J. Albertus, Eric D. Wolff

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


We report a case of renal failure in a newborn infant due to membranous glomerulonephritis. The patient was anuric in the first 3 weeks of life, after which renal function recovered. The serum of the mother contained IgG antibodies which reacted with tubular brush borders and glomeruli of adult and fetal human kidneys. Reactivity with renal epithelium from human kidneys was detected. We suggest that a transplacental, passive Heymann nephritis-like mechanism was the pathogenesis of the neonate's symptoms, although the antigen(s) involved was shown not to be gp 330 or any of the renal antigens known to be involved in experimental nephropathies.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalPediatric Nephrology
Issue number2
StatePublished - Mar 1990
Externally publishedYes


  • Glomerulonephritis
  • Kidney failure
  • Maternal-fetal exchange
  • Pathophysiology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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