Transplacental induction of membranous nephropathy in a neonate

Jeroen Nauta; Emile de Heer; William M. Baldwin; Fiebo J W ten Kate; Albertus J. Albertus; Eric D. Wolff

doi:10.1007/BF00858820

Transplacental induction of membranous nephropathy in a neonate

Jeroen Nauta, Emile de Heer, William M. Baldwin, Fiebo J W ten Kate, Albertus J. Albertus, Eric D. Wolff

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We report a case of renal failure in a newborn infant due to membranous glomerulonephritis. The patient was anuric in the first 3 weeks of life, after which renal function recovered. The serum of the mother contained IgG antibodies which reacted with tubular brush borders and glomeruli of adult and fetal human kidneys. Reactivity with renal epithelium from human kidneys was detected. We suggest that a transplacental, passive Heymann nephritis-like mechanism was the pathogenesis of the neonate's symptoms, although the antigen(s) involved was shown not to be gp 330 or any of the renal antigens known to be involved in experimental nephropathies.

Original language	English (US)
Pages (from-to)	111-116
Number of pages	6
Journal	Pediatric Nephrology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1007/BF00858820
State	Published - Mar 1990
Externally published	Yes

Keywords

Glomerulonephritis
Kidney failure
Maternal-fetal exchange
Pathophysiology

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Nephrology

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10.1007/BF00858820

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title = "Transplacental induction of membranous nephropathy in a neonate",

abstract = "We report a case of renal failure in a newborn infant due to membranous glomerulonephritis. The patient was anuric in the first 3 weeks of life, after which renal function recovered. The serum of the mother contained IgG antibodies which reacted with tubular brush borders and glomeruli of adult and fetal human kidneys. Reactivity with renal epithelium from human kidneys was detected. We suggest that a transplacental, passive Heymann nephritis-like mechanism was the pathogenesis of the neonate's symptoms, although the antigen(s) involved was shown not to be gp 330 or any of the renal antigens known to be involved in experimental nephropathies.",

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year = "1990",

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AU - Nauta, Jeroen

AU - de Heer, Emile

AU - Baldwin, William M.

AU - ten Kate, Fiebo J W

AU - Albertus, Albertus J.

AU - Wolff, Eric D.

PY - 1990/3

Y1 - 1990/3

N2 - We report a case of renal failure in a newborn infant due to membranous glomerulonephritis. The patient was anuric in the first 3 weeks of life, after which renal function recovered. The serum of the mother contained IgG antibodies which reacted with tubular brush borders and glomeruli of adult and fetal human kidneys. Reactivity with renal epithelium from human kidneys was detected. We suggest that a transplacental, passive Heymann nephritis-like mechanism was the pathogenesis of the neonate's symptoms, although the antigen(s) involved was shown not to be gp 330 or any of the renal antigens known to be involved in experimental nephropathies.

AB - We report a case of renal failure in a newborn infant due to membranous glomerulonephritis. The patient was anuric in the first 3 weeks of life, after which renal function recovered. The serum of the mother contained IgG antibodies which reacted with tubular brush borders and glomeruli of adult and fetal human kidneys. Reactivity with renal epithelium from human kidneys was detected. We suggest that a transplacental, passive Heymann nephritis-like mechanism was the pathogenesis of the neonate's symptoms, although the antigen(s) involved was shown not to be gp 330 or any of the renal antigens known to be involved in experimental nephropathies.

KW - Glomerulonephritis

KW - Kidney failure

KW - Maternal-fetal exchange

KW - Pathophysiology

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Transplacental induction of membranous nephropathy in a neonate

Abstract

Keywords

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