TY - JOUR
T1 - Transmural heterogeneity of Na+-Ca2+ exchange
T2 - Evidence for differential expression in normal and failing hearts
AU - Xiong, Wei
AU - Tian, Yanli
AU - DiSilvestre, Deborah
AU - Tomaselli, Gordon F.
PY - 2005/8/5
Y1 - 2005/8/5
N2 - Spatial electrical heterogeneity has a profound effect on normal cardiac electrophysiology and genesis of cardiac arrhythmias in diseased hearts. The Na+-Ca2+ exchanger (NCX) is a key linker, through Ca 2+ signaling, between contractility and arrhythmias. Here we characterize the differential transmural expression of NCX in normal and rapid pacing-induced failing canine hearts. Significant transmural heterogeneity of NCX was present in normal hearts, as NCX current density measured at +80 mV was significantly (P
AB - Spatial electrical heterogeneity has a profound effect on normal cardiac electrophysiology and genesis of cardiac arrhythmias in diseased hearts. The Na+-Ca2+ exchanger (NCX) is a key linker, through Ca 2+ signaling, between contractility and arrhythmias. Here we characterize the differential transmural expression of NCX in normal and rapid pacing-induced failing canine hearts. Significant transmural heterogeneity of NCX was present in normal hearts, as NCX current density measured at +80 mV was significantly (P
KW - Heart failure
KW - Na-Ca exchanger
KW - Transmural heterogeneity
UR - http://www.scopus.com/inward/record.url?scp=23344438459&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23344438459&partnerID=8YFLogxK
U2 - 10.1161/01.RES.0000175935.08283.27
DO - 10.1161/01.RES.0000175935.08283.27
M3 - Article
C2 - 16002750
AN - SCOPUS:23344438459
SN - 0009-7330
VL - 97
SP - 207
EP - 209
JO - Circulation Research
JF - Circulation Research
IS - 3
ER -