Transmural heterogeneity of Na+-Ca2+ exchange: Evidence for differential expression in normal and failing hearts

Wei Xiong, Yanli Tian, Deborah DiSilvestre, Gordon F. Tomaselli

Research output: Contribution to journalArticlepeer-review

Abstract

Spatial electrical heterogeneity has a profound effect on normal cardiac electrophysiology and genesis of cardiac arrhythmias in diseased hearts. The Na+-Ca2+ exchanger (NCX) is a key linker, through Ca 2+ signaling, between contractility and arrhythmias. Here we characterize the differential transmural expression of NCX in normal and rapid pacing-induced failing canine hearts. Significant transmural heterogeneity of NCX was present in normal hearts, as NCX current density measured at +80 mV was significantly (P

Original languageEnglish (US)
Pages (from-to)207-209
Number of pages3
JournalCirculation Research
Volume97
Issue number3
DOIs
StatePublished - Aug 5 2005

Keywords

  • Heart failure
  • Na-Ca exchanger
  • Transmural heterogeneity

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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