Transmural electrophysiologic and scar imaging on porcine heart with chronic infarction

Linwei Wang, Fady Dawoud, Ken C L Wong, Heye Zhang, Huafeng Liu, Albert C. Lardo, Pengcheng Shi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Myocardial scar is the most common substrate for malignant arrhythmia and cardiac arrest. Radiofrequency ablation, as one of the emerging mainstream therapies, is subject to limited success rate because of the inadequate assessment of scar substrates that currently relies on electrophysiologic (EP) map acquired on endocardial and occasionally epicardial surfaces. As myocardial scar is often complex with shapes varying with the depth of the myocardium, endocardial and epicardial maps may differ substantially, and may fail to identify mid-wall fibrosis that exist in ∼30% of patients with nonischemic cardiomyopathy. Alternatively, noninvasive and transmural scar delineation by current imaging techniques does not always show electrically altered functional substrates. Participating in CESC'11, we presented a new application of the previously developed method of transmural EP imaging, where epicardial unipolar electrograms acquired by CARTO together with MRI-derived ventricular anatomical data of a porcine heart with chronicle myocardial infarction were used for computing the transmural EP dynamics and subsequently classifying conduction blocks of the porcine heart. Validation was performed versus CARTO electroanatomic maps on the epicardium and endocardium, as well as DW-MRI enhanced anatomical scars. This allowed detailed examinations of the reported method in computing transmural EP anomalies using only surface data and without any condition-specific knowledge a priori, which could not be achieved with either current EP mapping or medical imaging techniques alone.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages23-32
Number of pages10
Volume7085 LNCS
DOIs
StatePublished - 2012
Event2nd International Workshop on Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges, STACOM 2011, Held in Conjunction with MICCAI 2011 - Toronto, ON, Canada
Duration: Sep 22 2011Sep 22 2011

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7085 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other2nd International Workshop on Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges, STACOM 2011, Held in Conjunction with MICCAI 2011
CountryCanada
CityToronto, ON
Period9/22/119/22/11

Keywords

  • DW-MRI
  • electroanatomic mapping
  • myocardial infarction
  • scar delineation
  • Transmural electrophysiology

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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