Transmural distribution of three-dimensional systolic strains in stunned myocardium

Reza Mazhari; Jeffrey H. Omens; Richard S. Pavelec; James W. Covell; Andrew D. McCulloch

Transmural distribution of three-dimensional systolic strains in stunned myocardium

Reza Mazhari, Jeffrey H. Omens, Richard S. Pavelec, James W. Covell, Andrew D. McCulloch

School of Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background - Regional function in stunned myocardium is usually thought to be more depressed in the endocardium than the epicardium. This has been attributed to the greater loss of blood flow at the endocardium during ischemia. Methods and Results - We measured transmural distributions of 3D systolic strains relative to local myofiber axes in open-chest anesthetized dogs before 15 minutes of left anterior descending coronary artery occlusion and during 2 hours of reperfusion. During ischemia, regional myocardial blood flow was reduced 84% at the endocardium and 32% at the epicardium (P

Original language	English (US)
Pages (from-to)	336-341
Number of pages	6
Journal	Circulation
Volume	104
Issue number	3
State	Published - Jul 17 2001

Keywords

Blood flow
Contractility
Diastole
Mechanics
Myocardial stunning

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

Cite this

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title = "Transmural distribution of three-dimensional systolic strains in stunned myocardium",

abstract = "Background - Regional function in stunned myocardium is usually thought to be more depressed in the endocardium than the epicardium. This has been attributed to the greater loss of blood flow at the endocardium during ischemia. Methods and Results - We measured transmural distributions of 3D systolic strains relative to local myofiber axes in open-chest anesthetized dogs before 15 minutes of left anterior descending coronary artery occlusion and during 2 hours of reperfusion. During ischemia, regional myocardial blood flow was reduced 84% at the endocardium and 32% at the epicardium (P",

keywords = "Blood flow, Contractility, Diastole, Mechanics, Myocardial stunning",

author = "Reza Mazhari and Omens, {Jeffrey H.} and Pavelec, {Richard S.} and Covell, {James W.} and McCulloch, {Andrew D.}",

year = "2001",

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T1 - Transmural distribution of three-dimensional systolic strains in stunned myocardium

AU - Mazhari, Reza

AU - Omens, Jeffrey H.

AU - Pavelec, Richard S.

AU - Covell, James W.

AU - McCulloch, Andrew D.

PY - 2001/7/17

Y1 - 2001/7/17

N2 - Background - Regional function in stunned myocardium is usually thought to be more depressed in the endocardium than the epicardium. This has been attributed to the greater loss of blood flow at the endocardium during ischemia. Methods and Results - We measured transmural distributions of 3D systolic strains relative to local myofiber axes in open-chest anesthetized dogs before 15 minutes of left anterior descending coronary artery occlusion and during 2 hours of reperfusion. During ischemia, regional myocardial blood flow was reduced 84% at the endocardium and 32% at the epicardium (P

AB - Background - Regional function in stunned myocardium is usually thought to be more depressed in the endocardium than the epicardium. This has been attributed to the greater loss of blood flow at the endocardium during ischemia. Methods and Results - We measured transmural distributions of 3D systolic strains relative to local myofiber axes in open-chest anesthetized dogs before 15 minutes of left anterior descending coronary artery occlusion and during 2 hours of reperfusion. During ischemia, regional myocardial blood flow was reduced 84% at the endocardium and 32% at the epicardium (P

KW - Blood flow

KW - Contractility

KW - Diastole

KW - Mechanics

KW - Myocardial stunning

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M3 - Article

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AN - SCOPUS:0035902546

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VL - 104

SP - 336

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JO - Circulation

JF - Circulation

IS - 3

ER -

Transmural distribution of three-dimensional systolic strains in stunned myocardium

Abstract

Keywords

ASJC Scopus subject areas

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