Transmission/disequilibrium tests incorporating unaffected offspring

Qinyu Wei, Yuanli Chen., Zheng Zeng, Chang Shu, Lu Long, Jianhua Lu, Yangxin Huang, Ping Yin, Brion Maher

Research output: Contribution to journalArticle

Abstract

We propose a new method for family-based tests of association and linkage called transmission/disequilibrium tests incorporating unaffected offspring (TDTU). This new approach, constructed based on transmission/disequilibrium tests for quantitative traits (QTDT), provides a natural extension of the transmission/ disequilibrium test (TDT) to utilize transmission information from heterozygous parents to their unaffected offspring as well as the affected offspring from ascertained nuclear families. TDTU can be used in various study designs and can accommodate all types of independent nuclear families with at least one affected offspring. When the study sample contains only case-parent trios, the TDTU is equivalent to TDT. Informative-transmission disequilibrium test (i-TDT) and generalized disequilibrium test(GDT) are another two methods that can use information of both unaffected offspring and affected offspring. In contract to i-TDT and GDT, the test statistic of TDTU is simpler and more explicit, and can be implemented more easily. Through computer simulations, we demonstrate that power of the TDTU is slightly higher compared to i-TDT and GDT. All the three methods are more powerful than method that uses affected offspring only, suggesting that unaffected siblings also provide information about linkage and association.

Original languageEnglish (US)
Article numbere114892
JournalPLoS One
Volume9
Issue number12
DOIs
StatePublished - Dec 23 2014

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Nuclear Family
testing
Contracts
Computer Simulation
Siblings
Parents
nuclear family
linkage (genetics)
Information use
quantitative traits
methodology
computer simulation
Statistics
statistics
experimental design
Computer simulation
Power (Psychology)

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Transmission/disequilibrium tests incorporating unaffected offspring. / Wei, Qinyu; Chen., Yuanli; Zeng, Zheng; Shu, Chang; Long, Lu; Lu, Jianhua; Huang, Yangxin; Yin, Ping; Maher, Brion.

In: PLoS One, Vol. 9, No. 12, e114892, 23.12.2014.

Research output: Contribution to journalArticle

Wei, Q, Chen., Y, Zeng, Z, Shu, C, Long, L, Lu, J, Huang, Y, Yin, P & Maher, B 2014, 'Transmission/disequilibrium tests incorporating unaffected offspring', PLoS One, vol. 9, no. 12, e114892. https://doi.org/10.1371/journal.pone.0114892
Wei Q, Chen. Y, Zeng Z, Shu C, Long L, Lu J et al. Transmission/disequilibrium tests incorporating unaffected offspring. PLoS One. 2014 Dec 23;9(12). e114892. https://doi.org/10.1371/journal.pone.0114892
Wei, Qinyu ; Chen., Yuanli ; Zeng, Zheng ; Shu, Chang ; Long, Lu ; Lu, Jianhua ; Huang, Yangxin ; Yin, Ping ; Maher, Brion. / Transmission/disequilibrium tests incorporating unaffected offspring. In: PLoS One. 2014 ; Vol. 9, No. 12.
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