Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressor

Justin Bailey, Karen O'Connell, Hung Chih Yang, Yefei Han, Jie Xu, Benjamin Jilek, Thomas M. Williams, Stuart Campbell Ray, Robert F Siliciano, Joel N Blankson

Research output: Contribution to journalArticle

Abstract

Elite suppressors (ES) are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain viral loads of + T-cell response in the ES appears to have prevented viral replication and thus the evolution toward a more fit variant. In addition, CD8+ T cells in the ES have selected for a rare mutation in an immunodominant HLA-B*27-restricted Gag epitope, which also has a negative impact on fitness. The results strongly suggest that through direct and indirect mechanisms, CD8+ T cells in some ES control HIV-1 isolates are capable of causing profound immunosuppression.

Original languageEnglish (US)
Pages (from-to)7395-7410
Number of pages16
JournalJournal of Virology
Volume82
Issue number15
DOIs
StatePublished - Aug 2008

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Human immunodeficiency virus 1
HIV-1
Acquired Immunodeficiency Syndrome
T-Lymphocytes
T-lymphocytes
HLA-B Antigens
Viral Load
Immunosuppression
Epitopes
immunosuppression
virus replication
viral load
epitopes
Mutation
mutation
HIV long-term survivors

ASJC Scopus subject areas

  • Immunology

Cite this

Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressor. / Bailey, Justin; O'Connell, Karen; Yang, Hung Chih; Han, Yefei; Xu, Jie; Jilek, Benjamin; Williams, Thomas M.; Ray, Stuart Campbell; Siliciano, Robert F; Blankson, Joel N.

In: Journal of Virology, Vol. 82, No. 15, 08.2008, p. 7395-7410.

Research output: Contribution to journalArticle

Bailey, Justin ; O'Connell, Karen ; Yang, Hung Chih ; Han, Yefei ; Xu, Jie ; Jilek, Benjamin ; Williams, Thomas M. ; Ray, Stuart Campbell ; Siliciano, Robert F ; Blankson, Joel N. / Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressor. In: Journal of Virology. 2008 ; Vol. 82, No. 15. pp. 7395-7410.
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