Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressor

Justin Bailey, Karen O'Connell, Hung Chih Yang, Yefei Han, Jie Xu, Benjamin Jilek, Thomas M. Williams, Stuart Campbell Ray, Robert F Siliciano, Joel N Blankson

Research output: Contribution to journalArticle

Abstract

Elite suppressors (ES) are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain viral loads of + T-cell response in the ES appears to have prevented viral replication and thus the evolution toward a more fit variant. In addition, CD8+ T cells in the ES have selected for a rare mutation in an immunodominant HLA-B*27-restricted Gag epitope, which also has a negative impact on fitness. The results strongly suggest that through direct and indirect mechanisms, CD8+ T cells in some ES control HIV-1 isolates are capable of causing profound immunosuppression.

Original languageEnglish (US)
Pages (from-to)7395-7410
Number of pages16
JournalJournal of Virology
Volume82
Issue number15
DOIs
Publication statusPublished - Aug 2008

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ASJC Scopus subject areas

  • Immunology

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