TY - JOUR
T1 - Transmission of HIV-1 Infections From Mothers to Infants in Haiti
T2 - Impact on Childhood Mortality and Malnutrition
AU - The CDS/JHU AIDS Project Team
AU - Halsey, Neal A.
AU - Boulos, Reginald
AU - Holt, Elizabeth
AU - Ruff, Andrea
AU - Brutus, Jean Robert
AU - Kissinger, Patricia
AU - Quinn, Thomas C.
AU - Coberly, Jacqueline S.
AU - Adrien, Mario
AU - Boulos, Carlo
PY - 1990/10/24
Y1 - 1990/10/24
N2 - Of 4588 pregnant women in a high-risk Haitian population, 443 (9.7%) were serologically positive for the human immunodeficiency virus type 1 (HIV-1). Infants born to women who were HIV-1 seropositive were more likely to be premature, of low birth weight, and malnourished at 3 and 6 months of age than were infants born to women who were HIV-1 seronegative. Increased mortality was observed in infants born to women who were HIV-1 seropositive by 3 months of age. At 12 months of age, 23.4% of the infants born to women who were HIV-1 seropositive had died compared with 10.8% of the infants born to women who were HIV-1 seronegative; at 24 months of age, the mortality rates were 31.3% and 14.2%, respectively. Maternal HIV-1 infections resulted in an 11.7% increase in the overall infant mortality rate in this population. The estimated mother-to-infant HIV-1 transmission rate in these breast-fed infants was 25%, similar to the rates reported for non—breast-fed populations in the United States and Europe.
AB - Of 4588 pregnant women in a high-risk Haitian population, 443 (9.7%) were serologically positive for the human immunodeficiency virus type 1 (HIV-1). Infants born to women who were HIV-1 seropositive were more likely to be premature, of low birth weight, and malnourished at 3 and 6 months of age than were infants born to women who were HIV-1 seronegative. Increased mortality was observed in infants born to women who were HIV-1 seropositive by 3 months of age. At 12 months of age, 23.4% of the infants born to women who were HIV-1 seropositive had died compared with 10.8% of the infants born to women who were HIV-1 seronegative; at 24 months of age, the mortality rates were 31.3% and 14.2%, respectively. Maternal HIV-1 infections resulted in an 11.7% increase in the overall infant mortality rate in this population. The estimated mother-to-infant HIV-1 transmission rate in these breast-fed infants was 25%, similar to the rates reported for non—breast-fed populations in the United States and Europe.
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U2 - 10.1001/jama.1990.03450160058029
DO - 10.1001/jama.1990.03450160058029
M3 - Article
C2 - 2214076
AN - SCOPUS:0025116294
SN - 0098-7484
VL - 264
SP - 2088
EP - 2092
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 16
ER -