Transmission of HIV-1 Infections From Mothers to Infants in Haiti: Impact on Childhood Mortality and Malnutrition

The CDS/JHU AIDS Project Team

Research output: Contribution to journalArticle

Abstract

Of 4588 pregnant women in a high-risk Haitian population, 443 (9.7%) were serologically positive for the human immunodeficiency virus type 1 (HIV-1). Infants born to women who were HIV-1 seropositive were more likely to be premature, of low birth weight, and malnourished at 3 and 6 months of age than were infants born to women who were HIV-1 seronegative. Increased mortality was observed in infants born to women who were HIV-1 seropositive by 3 months of age. At 12 months of age, 23.4% of the infants born to women who were HIV-1 seropositive had died compared with 10.8% of the infants born to women who were HIV-1 seronegative; at 24 months of age, the mortality rates were 31.3% and 14.2%, respectively. Maternal HIV-1 infections resulted in an 11.7% increase in the overall infant mortality rate in this population. The estimated mother-to-infant HIV-1 transmission rate in these breast-fed infants was 25%, similar to the rates reported for non—breast-fed populations in the United States and Europe.

Original languageEnglish (US)
Pages (from-to)2088-2092
Number of pages5
JournalJAMA: The Journal of the American Medical Association
Volume264
Issue number16
DOIs
StatePublished - Oct 24 1990

ASJC Scopus subject areas

  • Medicine(all)

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