Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: Case study and review of the literature

Mary Y. Armanios, Stuart A. Grossman, Stephen C. Yang, Barbara White, Arie Perry, Peter C. Burger, Jonathan B. Orens

Research output: Contribution to journalArticle

Abstract

Donor-acquired solid organ malignancy is a rare complication of organ transplantation. We report a case of a patient who received bilateral lung transplants for pulmonary fibrosis from a donor with known glioblastoma multiforme (GBM). The lungs, heart, liver, and kidneys were harvested after a lethal intracranial bleed and accepted for transplantation by four centers. An enlarged hilar lymph node sampled at the time of transplant was found to contain GBM. Four months later, the patient developed diffuse interstitial pulmonary infiltrates with mediastinal lymphadenopathy. Lung biopsy confirmed metastatic GBM. The patient died 2 weeks after the diagnosis was established. The patient receiving the donor liver also developed GBM. We present a case study, review of the literature, and suggested interventions to minimize the risk of transmission.

Original languageEnglish (US)
Pages (from-to)259-263
Number of pages5
JournalNeuro-oncology
Volume6
Issue number3
DOIs
StatePublished - Jul 2004

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

Fingerprint Dive into the research topics of 'Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: Case study and review of the literature'. Together they form a unique fingerprint.

  • Cite this