Transmission of an azole-resistant isogenic strain of Candida albicans among human immunodeficiency virus-infected family members with oropharyngeal candidiasis

Frank Michael C. Müller, Miki Kasai, Andrea Francesconi, Beth Brillante, Maureen Roden, Joanne Peter, Stephen J. Chanock, Thomas J. Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

We report transmission of an azole-resistant, isogenic strain of Candida albicans in a human immunodeficiency virus (HIV)-infected family of two children with symptomatic oropharyngeal candidiasis and a mother with asymptomatic colonization over a 5-year period. These findings were confirmed by three different molecular epidemiology methods: interrepeat PCR, Southern hybridization with a C. albicans repetitive element 2 probe, and electrophoretic karyotyping. This study contributes to an evolving understanding of the mode of transmission of C. albicans, particularly in children, and underscores the importance of monitoring specimens from family members of HIV-infected patients.

Original languageEnglish (US)
Pages (from-to)3405-3408
Number of pages4
JournalJournal of clinical microbiology
Volume37
Issue number10
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Microbiology (medical)

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