TY - JOUR
T1 - Transmission of an azole-resistant isogenic strain of Candida albicans among human immunodeficiency virus-infected family members with oropharyngeal candidiasis
AU - Müller, Frank Michael C.
AU - Kasai, Miki
AU - Francesconi, Andrea
AU - Brillante, Beth
AU - Roden, Maureen
AU - Peter, Joanne
AU - Chanock, Stephen J.
AU - Walsh, Thomas J.
PY - 1999
Y1 - 1999
N2 - We report transmission of an azole-resistant, isogenic strain of Candida albicans in a human immunodeficiency virus (HIV)-infected family of two children with symptomatic oropharyngeal candidiasis and a mother with asymptomatic colonization over a 5-year period. These findings were confirmed by three different molecular epidemiology methods: interrepeat PCR, Southern hybridization with a C. albicans repetitive element 2 probe, and electrophoretic karyotyping. This study contributes to an evolving understanding of the mode of transmission of C. albicans, particularly in children, and underscores the importance of monitoring specimens from family members of HIV-infected patients.
AB - We report transmission of an azole-resistant, isogenic strain of Candida albicans in a human immunodeficiency virus (HIV)-infected family of two children with symptomatic oropharyngeal candidiasis and a mother with asymptomatic colonization over a 5-year period. These findings were confirmed by three different molecular epidemiology methods: interrepeat PCR, Southern hybridization with a C. albicans repetitive element 2 probe, and electrophoretic karyotyping. This study contributes to an evolving understanding of the mode of transmission of C. albicans, particularly in children, and underscores the importance of monitoring specimens from family members of HIV-infected patients.
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U2 - 10.1128/jcm.37.10.3405-3408.1999
DO - 10.1128/jcm.37.10.3405-3408.1999
M3 - Article
C2 - 10488220
AN - SCOPUS:17144433571
SN - 0095-1137
VL - 37
SP - 3405
EP - 3408
JO - Journal of clinical microbiology
JF - Journal of clinical microbiology
IS - 10
ER -